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Radiation Therapy
60 Gy radiotherapy for Brain Tumor
Phase 2
Waitlist Available
Led By C. Leland Rogers, MD
Research Sponsored by Radiation Therapy Oncology Group
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from registration to 3 years
Awards & highlights
Study Summary
This trial is comparing observation with radiation therapy to see which is more effective in treating patients with meningioma.
Eligible Conditions
- Brain Tumor
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ from registration to 3 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from registration to 3 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Progression-free Survival Rate at 3 Years
Secondary outcome measures
Adherence to Protocol-specific Target and Normal Tissue Radiotherapy Parameters
Concordance Between Central and Parent Institution Histopathologic Grading/Subtyping
Greatest Single Dimension From MRI as Assessed by Central Neuroradiology Review at Diagnosis, at Progression, and at 3 Years
+7 moreTrial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Intermediate RiskExperimental Treatment1 Intervention
54 Gy radiotherapy
Group II: High RiskExperimental Treatment1 Intervention
60 Gy radiotherapy
Group III: Low RiskActive Control1 Intervention
No treatment given.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
60 Gy radiotherapy
2009
Completed Phase 2
~250
54 Gy radiotherapy
2009
Completed Phase 2
~250
Find a Location
Who is running the clinical trial?
Radiation Therapy Oncology GroupLead Sponsor
190 Previous Clinical Trials
64,683 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,932,909 Total Patients Enrolled
NRG OncologyOTHER
231 Previous Clinical Trials
100,608 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have received radiation treatment in the past on your head or brain.You are unable to receive gadolinium, a contrast agent used in certain medical tests.If you have lupus or scleroderma and are at a higher risk for complications, you cannot participate in the study.You have a type of brain tumor called extracranial meningioma.You have a type of tumor called hemangiopericytoma.You have serious health conditions that are currently causing problems.You have a severe lung disease or a recent respiratory illness that has required hospitalization or would prevent you from receiving the study treatment.You have severe liver problems that cause jaundice and/or issues with blood clotting. However, in this study, you don't need to take any specific tests to check your liver function or blood clotting.
Research Study Groups:
This trial has the following groups:- Group 1: Low Risk
- Group 2: Intermediate Risk
- Group 3: High Risk
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many venues are currently hosting this research study?
"This medical trial is taking place at Kimmel Cancer Center at Thomas Jefferson University - Philadelphia in Philadelphia, Cross Cancer Institute at University of Alberta in Edmonton, and Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center in Savannah. In addition to these three sites, there are 75 other locations hosting this research."
Answered by AI
Is there any availability for prospective participants in this research?
"Information hosted on clinicaltrials.gov reveals that this medical study, first posted in June 2009 and last updated on May 14th 2021, is not recruiting patients at present but there are 156 other trials actively enrolling participants."
Answered by AI
Has the Federal Drug Administration given permission for 54 Gy radiotherapy?
"The safety of 54 Gy radiotherapy was scored as a 2 due to there being limited evidence supporting its efficacy and some data pointing towards its general safety."
Answered by AI
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