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GFB-887 for Nephritis

Phase 2
Waitlist Available
Research Sponsored by Goldfinch Bio, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 3 years
Awards & highlights

Study Summary

This trial is testing a new drug for patients with FSGS or TR-MCD. The goal is to see if it is safe and well tolerated over the long term.

Eligible Conditions
  • Nephritis
  • Glomerulonephritis
  • Nephrotic Syndrome
  • Kidney Disease
  • Glomerulosclerosis
  • Focal Segmental Glomerulosclerosis
  • Lipoid Nephrosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence and severity of adverse events
Secondary outcome measures
Changes in estimated glomerular filtration rate (eGFR) including slope
Percent reduction in urine protein:creatinine ratio (UPCR) from baseline
Proportion of participants achieving complete remission status
+9 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: 200 mg Dose CohortExperimental Treatment1 Intervention
Participants who received GFB-887 or placebo in GFB-887-201 will receive GFB-887 at a daily dose level of 200 mg regardless of original dose level.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
GFB-887
2019
Completed Phase 1
~70

Find a Location

Who is running the clinical trial?

Goldfinch Bio, Inc.Lead Sponsor
4 Previous Clinical Trials
225 Total Patients Enrolled
1 Trials studying Nephritis
96 Patients Enrolled for Nephritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases
2021. "An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04950114.
~8 spots leftby Apr 2025
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