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RAIN-32 for Head and Neck Cancers
Study Summary
This trial is testing a new drug to see if it is safe and effective in patients with solid tumors that have not responded to other treatments.
- Head and Neck Cancers
- Bile Duct Cancer
- Adrenocortical Cancer
- Solid Tumors
- Lung Adenocarcinoma
- Sarcoma
- Bladder Cancer
- Stomach Cancer
- Breast Cancer
- Ovarian Cancer
- Cervical Cancer
- Non-Small Cell Lung Cancer
- Melanoma
- Pancreatic Cancer
- Gene Amplification
- Testicular Cancer
- Biliary Tract Cancer
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- You have a heart condition that is not well-managed or is serious.You have a gastrointestinal condition that could make it difficult for your body to absorb milademetan, according to the investigator.You have taken medication that targets a protein called MDM2 in the past.You have high blood pressure that is not well managed.You have received radiation therapy with the intent to cure within the last 4 weeks or received palliative radiation therapy.You have had severe chest pain (angina) that was not well managed within the past 6 months.
- Group 1: Milademetan (RAIN-32)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the federal regulatory agency cleared RAIN-32 for public use?
"Our team at Power assigned RAIN-32 a score of 2 for safety on our scale, as the Phase 2 trial offers some assurance in its safety but does not yet have any data to back efficacy."
How many US hospitals are carrying out this research protocol?
"This study is now looking for participants at 10 distinct medical sites, which are located in Saint Louis, Houston and Boston plus 7 other cities. To reduce the amount of travel you need to undertake if accepted into this trial, it would be prudent to opt for a site located close to you."
Is this a pioneering endeavor in clinical trials?
"The first research on RAIN-32 was conducted in 2021 and sponsored by Rain Therapeutics Inc. After the completion of this initial study, which included 160 participants, it successfully gained Phase 3 drug approval. At present there are two ongoing trials for RAIN-32 being held across 32 cities and 15 countries worldwide."
Can you provide any information on prior experiments related to RAIN-32?
"In 2021, the first RAIN-32 experiment was conducted at Leon Berard Center. Across 4 different trials to date, two of which are still in progress with a focus on Saint Louis, Missouri."
How many participants are enrolled in the research currently?
"Affirmative. Clinicaltrials.gov reveals that this clinical trial, which was originally published on November 1st 2021, is actively searching for volunteers. 65 participants are needed from 10 medical sites to complete the research objectives of this project."
Are there any opportunities currently available to participate in this investigation?
"Affirmative. Referring to the information hosted on clinicaltrials.gov, it is evident that this medical experiment commenced recruiting subjects from November 1st 2021 and was recently updated in November 9th 2022 with a requirement for 65 participants across 10 sites."
Who else is applying?
What state do they live in?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
What questions have other patients asked about this trial?
Why did patients apply to this trial?
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