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Monoclonal Antibodies

PF-04518600 for Cancer

Phase 1 & 2
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to approximately 24 months
Awards & highlights

Study Summary

This trial is testing the safety and effectiveness of the drug avelumab when used with other cancer immunotherapies. The goal is to see if it can help treat patients with locally advanced or metastatic solid tumors.

Eligible Conditions
  • Advanced Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to approximately 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to approximately 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of participants with Dose-Limiting Toxicities (DLT)
Objective Response - Number of Participants With Objective Response
Secondary outcome measures
Anti-Drug Antibody (ADA) levels of PF-04518600
Anti-Drug Antibody (ADA) levels of PF-05082566
Anti-Drug Antibody (ADA) levels of avelumab (MSB0010718C)
+11 more

Trial Design

19Treatment groups
Experimental Treatment
Group I: Combination D Dose expansion cohortsExperimental Treatment3 Interventions
PF-05082566 + PF-04518600 + avelumab in selected tumor types
Group II: Combination D Dose escalation cohortsExperimental Treatment3 Interventions
PF-05082566 + PF-04518600 + avelumab in selected tumor types
Group III: Combination C Dose expansion cohortsExperimental Treatment2 Interventions
PD 0360324 + aveluamb in selected tumor types
Group IV: Combination C Dose escalation cohortsExperimental Treatment2 Interventions
PD 0360324 + avelumab in selected tumor types
Group V: Combination B Expansion CohortsExperimental Treatment2 Interventions
PF-04518600 + avelumab in selected tumor types
Group VI: Combination B Dose EscalationExperimental Treatment2 Interventions
PF-04518600 + avelumab in selected tumor types
Group VII: Cohort F3Experimental Treatment3 Interventions
CMP-001 +avelumab+PF-04518600 in SCCHN
Group VIII: Cohort F2Experimental Treatment3 Interventions
CMP-001+avelumab+utomilumab in SCCHN
Group IX: Cohort F1Experimental Treatment2 Interventions
CMP-001 +avelumab in SCCHN
Group X: Cohort A9Experimental Treatment2 Interventions
NSCLC first-line Stage IV treated with avelumab +utomilumab (sequential starting with utomilumab monotherapy followed by combination)
Group XI: Cohort A8Experimental Treatment2 Interventions
NSCLC first-line Stage IV treated with avelumab +PF-05082566
Group XII: Cohort A7Experimental Treatment2 Interventions
SCLC that has progressed after at least 1 line of platinum-containing therapy treated with avelumab +utomilumab
Group XIII: Cohort A6Experimental Treatment2 Interventions
TNBC patients treated with avelumab + utomilumab
Group XIV: Cohort A5Experimental Treatment2 Interventions
SCCHN patients treated with avelumab + utomilumab
Group XV: Cohort A4Experimental Treatment2 Interventions
Melanoma patients treated with avelumab +utomilumab
Group XVI: Cohort A3Experimental Treatment2 Interventions
NSCLC patients treated with avelumab + utomilumab (Dose level 3)
Group XVII: Cohort A2Experimental Treatment2 Interventions
NSCLC patients treated with avelumab + utomilumab (Dose level 2)
Group XVIII: Cohort A10Experimental Treatment2 Interventions
NSCLC first-line Stage IV treated with avelumab + utomilumab (sequential starting with avelumab monotherapy followed by combination)
Group XIX: Cohort A1Experimental Treatment2 Interventions
NSCLC patients treated with avelumab + utomilumab (Dose level 1)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ivuxolimab
Not yet FDA approved
PD 0360324
2007
Completed Phase 1
~80
CMP-001
2018
Completed Phase 2
~380
Avelumab
FDA approved
Utomilumab
Not yet FDA approved

Find a Location

Who is running the clinical trial?

PfizerLead Sponsor
4,570 Previous Clinical Trials
10,910,031 Total Patients Enrolled
Pfizer CT.gov Call CenterStudy DirectorPfizer
3,475 Previous Clinical Trials
8,091,145 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants is the clinical trial currently recruiting?

"This research effort is no longer recruiting participants, having been posted first on 11th September 2015 and last updated on 21st July 2022. Patients searching for other clinical trials should be aware that there are 2468 cancer-related studies currently active as well as 114 involving PF-04518600 which require volunteers."

Answered by AI

Is this a unique clinical trial?

"A search of clinicaltrials.gov reveals that the drug PF-04518600 is present in 114 active studies across 1024 cities and 52 nations. The trail for this medication was first initiated by EMD Serono Research & Development Institute, Inc. back in 2014; it successfully completed Phase 2 trials with 204 participants involved. 56 additional experiments have been conducted since then."

Answered by AI

What are the major goals that this clinical experiment is attempting to accomplish?

"This clinical trial is assessing its primary outcome, the Objective Response - Number of Participants With Objective Response, during an 8-week period for Combination A to D and a 4-week period for Combination F. Secondary outcomes include examining anti-drug antibody (ADA) levels of avelumab (MSB0010718C), trough plasma concentration at the end of PF-05082566 doses, as well as maximum concentrations of PF-05082566 in blood samples."

Answered by AI

Are any openings left for participants in this trial?

"According to a clinicaltrials.gov review, the date of this medical trial's last update was July 21st 2022 and it is no longer in need of participants. Nevertheless, there are presently 2,582 other trials actively recruiting patients."

Answered by AI

What prior research endeavors have been undertaken that involve PF-04518600?

"PF-04518600 was first tested in 2014 at the Port Macquarie Base Hospital, and there have been 56 concluded studies. There are currently 114 ongoing trials being conducted from multiple sites, notably including New york City."

Answered by AI

How many venues are conducting this trial research?

"At this moment in time, 62 clinical trial sites across the USA are recruiting patients. These locations span from New york to Goldsboro and Vista as well as additional unspecified areas. Prospective participants should endeavour to choose a nearby site so as to reduce commuting obligations."

Answered by AI
~43 spots leftby Apr 2025