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Minocycline for Multiple Myeloma

Phase 2

Waitlist Available

Led By Sheeba K. Thomas, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 10 weeks

Awards & highlights

Study Summary

This trial is testing whether Minocin can help control nerve damage from thalidomide and/or bortezomib.

Eligible Conditions

Multiple Myeloma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 10 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~10 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Difference Between Touch Detection Thresholds From the Sensorimotor Evaluation at Baseline and After 10 weeks of Induction Therapy

Side effects data

From 2016 Phase 4 trial • 10 Patients • NCT02124811

40%

Inpatient psychiatric hospitalization

20%

Hospitalization due to ischemic colitis

20%

Hypotension

100%

80%

60%

40%

20%

Study treatment Arm

Low CRP

High CRP

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Minocycline GroupExperimental Treatment1 Intervention

200 mg orally for 1 dose, then 100 mg orally every 12 hours for 10 weeks.

Group II: Placebo GroupPlacebo Group1 Intervention

1 dose on first day of induction therapy, then every 12 hours for 10 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Minocycline

2005

Completed Phase 4

~1000

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,966 Previous Clinical Trials

1,804,702 Total Patients Enrolled

76 Trials studying Multiple Myeloma

5,738 Patients Enrolled for Multiple Myeloma

National Cancer Institute (NCI)NIH

13,654 Previous Clinical Trials

40,933,074 Total Patients Enrolled

578 Trials studying Multiple Myeloma

188,651 Patients Enrolled for Multiple Myeloma

Sheeba K. Thomas, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical issues is Minocycline usually used to address?

"Minocycline is a viable therapy for various conditions, including rocky mountain spotted fever, q fever and dental root planing."

Answered by AI

What reports have been generated about the efficacy of Minocycline?

"Currently, 21 separate clinical trials are exploring the effects of Minocycline. 6 of those experiments have advanced to Phase 3 status and can be found at 37 different medical centres located primarily in Guangzhou, Guangdong province."

Answered by AI

Are there any enrollment opportunities for this research initiative?

"Inferences from clinicaltrials.gov suggest that this medical trial is not currently enrolling volunteers, despite being initially posted on the 25th of January 2011 and recently updated on June 29th 2022. However, there are 839 other studies searching for participants at present."

Answered by AI

What is the capacity of this research investigation?

"This clinical trial is currently not enrolling patients. It was posted on the January 25th 2011 and last updated on June 29th 2022. For those searching for alternate studies, 818 trials are actively accepting participants with multiple myeloma while 21 tests are recruiting individuals given Minocycline medications."

Answered by AI

What potential health risks are associated with taking Minocycline?

"Based on our team's assessment, minocycline was assigned a safety score of 2. This is due to the lack of established efficacy data from Phase 2 trials, although there are some studies that suggest its safety."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Prevention of Treatment Induced Neuropathy in Multiple Myeloma

2011. "Prevention of Treatment Induced Neuropathy in Multiple Myeloma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01283997.

All > Prevention > Myeloma