← Back to Search

Tetracycline Antibiotic

Doxycycline for Coronary Aneurysm

Phase 2
Waitlist Available
Led By Andras Bratincsak, MD PhD
Research Sponsored by Hawaii Pacific Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months
Awards & highlights

Study Summary

This trial will study whether doxycycline can prevent coronary artery enlargement in children with KD. 50 children will be treated with doxy for 3 weeks and monitored for changes.

Eligible Conditions
  • Coronary Aneurysm
  • Kawasaki Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Coronary artery diameter change
Secondary outcome measures
Assess a change in TIMP level
Assess the change in MMP-9 level

Side effects data

From 2021 Phase 4 trial • 26 Patients • NCT04167085
4%
Sinus infection
4%
Metastatic lung cancer dx
4%
Blurred vision
4%
Foot infection
4%
Emesis
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Doxycycline
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: DoxycyclineExperimental Treatment1 Intervention
These patients will receive doxycycline at the acute phase of their disease
Group II: PlaceboActive Control1 Intervention
The comparative arm of the study will receive standard care and placebo for Kawasaki disease, but not doxycycline
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
FDA approved

Find a Location

Who is running the clinical trial?

Hawaii Pacific HealthLead Sponsor
9 Previous Clinical Trials
551 Total Patients Enrolled
Andras Bratincsak, MD PhD5.03 ReviewsPrincipal Investigator - Hawaii Pacific Health
Hawaii Pacific Health
5Patient Review
I am so grateful to Dr. B and his team for their amazing work in repairing my son's heart. He is now up and about, just as Dr. B said he would be. Thank you, thank you, thank you!

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Contemporary Clinical TrialsJournal
Study Design and Rationale to Assess Doxycycline Efficacy in Preventing Coronary Artery Lesions in Children with Kawasaki Disease (DEAL Trial) – A Phase II Clinical Trial
Bratincsak, Andras, Blair N. Limm-Chan, Vivek R. Nerurkar, Lauren L. Ching, Venu D. Reddy, Eunjung Lim, Ralph V. Shohet, and Marian E. Melish. 2018. “Study Design and Rationale to Assess Doxycycline Efficacy in Preventing Coronary Artery Lesions in Children with Kawasaki Disease (DEAL Trial) – A Phase II Clinical Trial”. Contemporary Clinical Trials. Elsevier BV. doi:10.1016/j.cct.2017.11.014.
clinicaltrials.govStudy
Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Andras Bratincsak, MD, PhD 2013. "Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01917721.
All > Kawasaki Disease
~4 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top