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FAAH Inhibitor

PF-04457845 for Cannabis Use Disorder (FAAH-I MULTI Trial)

Phase 2
Waitlist Available
Led By Deepak C D'Souza, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 18-60 years, inclusive.
Male or Female.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 1, week 3, week 5, week 7, and week 9 visits
Awards & highlights

FAAH-I MULTI Trial Summary

This trial is testing a new drug to treat cannabis use disorder. It is 8 weeks long, and people taking the drug will be compared to those taking a placebo.

Eligible Conditions
  • Cannabis Use Disorder

FAAH-I MULTI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

FAAH-I MULTI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 1, week 3, week 5, week 7, and week 9 visits
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 1, week 3, week 5, week 7, and week 9 visits for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time Line Follow Back (TLFB) for Cannabis Use
Urinary Levels of THC-COOH (ng/ml)

FAAH-I MULTI Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: PF-04457845Active Control1 Intervention
Subjects will be randomized to Fatty Acid Amide Hydrolase (FAAH) Inhibitor; 4 mg PF-04457845 QD x 8 weeks
Group II: PlaceboPlacebo Group1 Intervention
Subjects will be randomized to placebo

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityOTHER
2,245 Previous Clinical Trials
14,815,878 Total Patients Enrolled
Medical University of South CarolinaOTHER
929 Previous Clinical Trials
7,393,593 Total Patients Enrolled
Yale UniversityLead Sponsor
1,839 Previous Clinical Trials
2,728,814 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being helped by this medical research?

"The clinical trial is currently recruiting patients and was last updated on February 9th, 2022. The study is looking for 237 participants from 5 different sites."

Answered by AI

Are there any open positions for patients in this particular clinical trial?

"The clinical trial is presently recruiting patients, with the posting date being 1/14/2019 and the most recent edit on 2/9/2022."

Answered by AI

Could you please list other scientific research that has been completed on PF-04457845?

"PF-04457845 was first studied in 2019 by researchers at Johns Hopkins University. So far, there have been a total of 174 completed trials. As of now, there is 1 active study, with many of these studies taking place in New york City."

Answered by AI

Does this research project include elderly individuals as test subjects?

"From the information provided by the study's inclusion criteria, the minimum age requirement for participants is 18 and the maximum is 60."

Answered by AI

If I qualify, may I take part in this experiment?

"The trial team is looking for 237 individuals aged 18-60 who have cannabis use disorders."

Answered by AI

Has PF-04457845 received regulatory approval from the FDA?

"PF-04457845 is still being tested for efficacy in Phase 2 trials, so it only received a safety score of 2."

Answered by AI

On how many different continents is this research project being conducted?

"In addition to other research sites, this clinical trial is enrolling patients at Johns Hopkins in New york City, Columbia University Medical College / New York State Psychiatric Institute in Charleston, South carolina, and the Medical University of South Carolina in New Haven, Connecticut."

Answered by AI
~37 spots leftby Mar 2025