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Antibiotic

Minocycline for Age-Related Macular Degeneration

Phase 2

Waitlist Available

Led By Tiarnan DL Keenan, M.D.

Research Sponsored by National Eye Institute (NEI)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up run-in phase (baseline to month 9) before initiation of ip and 24 months treatment phase after initiation of ip (month 9 to month 33)

Awards & highlights

Study Summary

This trial will last at least 3 years.

Eligible Conditions

Age-Related Macular Degeneration

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ run-in phase (baseline to month 9) before initiation of ip and 24 months treatment phase after initiation of ip (month 9 to month 33)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~run-in phase (baseline to month 9) before initiation of ip and 24 months treatment phase after initiation of ip (month 9 to month 33)

This trial's timeline: 3 weeks for screening, Varies for treatment, and run-in phase (baseline to month 9) before initiation of ip and 24 months treatment phase after initiation of ip (month 9 to month 33) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Difference in Square-Root Transformed GA Area Expansion Rates in the Study Eye Between the Treatment Phase and Run-in Phase Based on Fundus Autofluorescence (FAF)

Secondary outcome measures

Difference in Square-root Transformed GA Area Expansion Rates Between the Treatment Phase and Run-in Phase Based on Fundus Autofluorescence (FAF)

Difference in the Mean Rate of Change in Best Corrected Visual Acuity (BCVA) Between the Treatment Phase and Run-in Phase

Difference in the Mean Rate of Change in Low-Luminance Visual Acuity (LLVA) Between the Treatment Phase and Run-in Phase

+2 more

Side effects data

From 2016 Phase 4 trial • 10 Patients • NCT02124811

40%

Inpatient psychiatric hospitalization

20%

Hospitalization due to ischemic colitis

20%

Hypotension

100%

80%

60%

40%

20%

Study treatment Arm

Low CRP

High CRP

Trial Design

1Treatment groups

Experimental Treatment

Group I: MinocyclineExperimental Treatment1 Intervention

Oral administration of minocycline.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Minocycline

2005

Completed Phase 4

~1000

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Eye Institute (NEI)Lead Sponsor

546 Previous Clinical Trials

1,401,891 Total Patients Enrolled

Tiarnan DL Keenan, M.D.Principal InvestigatorNational Eye Institute (NEI)

3 Previous Clinical Trials

739 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients being accepted for this experimental program at this time?

"The trial mentioned is no longer recruiting patients, as noted on clinicaltrials.gov. The study was active from December 2016 to September 2020. 350 other trials are still ongoing and presently looking for participants."

Answered by AI

Is Minocycline's risk potential something that people should be aware of?

"Minocycline's efficacy hasn't been proven yet, but it did receive a score of 2 because there is some data attesting to its safety."

Answered by AI

How many people have enrolled in this trial so far?

"As of now, this study has completed recruitment for participants. This research was first made public on December 14th, 2016 but the information was last updated September 22nd of this year. If you are interested in other trials, there are 329 studies looking for patients with atrophy and 21 clinical trials searching for individuals to test Minocycline."

Answered by AI

Minocycline is usually prescribed for what reason?

"Minocycline is most often used to treat rocky mountain spotted fever; however, it has also been effective in treating other conditions like q fever and respiratory tract infections."

Answered by AI

What other clinical research has been conducted using Minocycline?

"There are currently 21 clinical trials underway that focus on Minocycline. These studies are taking place in 37 locations around the world, with 6 of them being Phase 3 trials."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

2016. "Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02564978.