This trial looks at whether anakinra can help decrease the occurrence of CRS and neurotoxicity in patients with B-cell non-Hodgkin lymphoma who are receiving CAR-T therapy.
- Non-Hodgkin's Lymphoma
1 Primary · 8 Secondary · Reporting Duration: Up to 28 days after liso-cel infusion
Side Effects for
2 Treatment Groups
Prevention (anakinra, axicabtagene ciloleucel)
1 of 2
Prevention (anakinra, lisocabtagene maraleucel)
1 of 2
25 Total Participants · 2 Treatment Groups
Primary Treatment: Anakinra · No Placebo Group · Phase 2
Who is running the clinical trial?
Age 18+ · All Participants · 11 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
To what extent is enrollment being pursued for this clinical experiment?
"Affirmative, according to clinicaltrials.gov this study is still seeking participants. The initial post was created on December 27th 2021 and the most recent adjustment occurred September 19th 2022. 25 individuals are required from 1 site for the trial's completion." - Anonymous Online Contributor
What pathologies is Anakinra typically prescribed to address?
"Anakinra is widely prescribed for treating b-cell lymphomas and has proven successful in helping patients with systemic juvenile idiopathic arthritis (sjia), neonatal-onset multisystem inflammatory disease (nomid), and steroids." - Anonymous Online Contributor
Is this the inaugural trial of its kind?
"Since 2015, Anakinra has been extensively researched. The first clinical trial was sponsored by Kite, A Gilead Company, and completed in the same year with 307 participants. Thanks to its success, Phase 1 & 2 drug approval were granted and now there are 43 active studies involving 247 cities across 32 nations worldwide." - Anonymous Online Contributor
Has the FDA sanctioned Anakinra for medicinal use?
"While Phase 2 trials do not provide efficacy data, there are some safety findings which allow us to rate Anakinra's safety a score of 2." - Anonymous Online Contributor
Are there any vacancies for prospective participants in this trial?
"Yes, according to clinicaltrials.gov, this trial is actively recruiting participants as of today. The project was initially posted on December 27th 2021 and has since been amended; 25 patients are now being recruited from a single site." - Anonymous Online Contributor
Are there any extant clinical trials that involve Anakinra?
"At present, there are 43 Anakinra clinical trials in progress with 8 of those active studies being conducted at Phase 3. These tests primarily reside in Paris, Ile-De-France, yet over 650 other medical locations across the world also host these treatments." - Anonymous Online Contributor