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CAR T-cell Therapy

Tisagenlecleucel for Non-Hodgkin's Lymphoma (JULIET Trial)

Phase 2
Waitlist Available
Research Sponsored by Novartis Pharmaceuticals
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

JULIET Trial Summary

This trial is testing a new treatment for people with a certain type of blood cancer that has come back or has not responded to other treatments.

Eligible Conditions
  • Non-Hodgkin's Lymphoma

JULIET Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall Response Rate (ORR)
Secondary outcome measures
Duration of overall response (DOR)
Event free survival (EFS)
In vivo cellular Pharmacokinetic (PK) profile of CTL019 transduced cells into target tissues
+7 more

JULIET Trial Design

1Treatment groups
Experimental Treatment
Group I: TisagenlecleucelExperimental Treatment2 Interventions
Adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who will receive tisagenlecleucel.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tisagenlecleucel
2019
Completed Phase 2
~360
Lymphodepleting chemotherapy
2014
Completed Phase 2
~130

Find a Location

Who is running the clinical trial?

Novartis PharmaceuticalsLead Sponsor
2,855 Previous Clinical Trials
4,197,628 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being researched in this clinical trial?

"As of October 2nd, 2022, this study is no longer seeking candidates. It was initially posted on July 29th, 2015. If you are looking for other trials, there are 1810 lymphoma studies and 18 CTL019 clinical trials currently recruiting patients."

Answered by AI

What other ongoing research is being conducted with CTL019?

"Currently, there are 18 ongoing clinical trials researching CTL019. Out of those active studies, 2 have reached Phase 3 status. The majority of the trials for CTL019 are based in Washington D.C., but 331 locations across the globe are running medical research for this treatment."

Answered by AI

Can you give me a breakdown of where this trial is being conducted?

"Various hospitals and clinics are participating in this trial, such as University of California San Francisco SC-4 in San Francisco, California; Novartis Investigative Site in Hamilton, Ontario; and University of Chicago Medical Center, Hematology & Oncology in Chicago, Illinois."

Answered by AI

Has this particular type of test been done before?

"Since 2015, CTL019 has undergone 19 different clinical trials. The first was sponsored by Novartis Pharmaceuticals and took place in 2015 with 97 participants. Phase 2 approval was granted after the successful completion of the first study. Currently, there are 18 ongoing trials being conducted in 115 cities and 22 countries worldwide."

Answered by AI

What is the level of danger that CTL019 poses to patients?

"CTL019's safety is supported by some data, but as this is only a Phase 2 trial, there is no evidence yet of efficacy. We've given it a score of 2."

Answered by AI

Are new participants being sought for this clinical trial?

"Although this particular study is no longer recruiting patients, the data available on clinicaltrials.gov suggests that it was last edited on 10/2/2022. There are 1828 other trials which are actively looking for participants right now."

Answered by AI
Recent research and studies
~12 spots leftby Apr 2025