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Enzyme

Glucarpidase for Lymphoma

Phase 2

Waitlist Available

Research Sponsored by Fox Chase Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

Study Summary

This trial is testing whether using glucarpidase can prevent methotrexate-related toxicities in lymphoma patients with brain involvement.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Rate of methotrexate clearance

Secondary outcome measures

Progression free survival

Trial Design

1Treatment groups

Experimental Treatment

Group I: GlucarpidaseExperimental Treatment1 Intervention

Prophylactic glucarpidase treatment

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Glucarpidase

2008

Completed Phase 3

~50

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Fox Chase Cancer CenterLead Sponsor

227 Previous Clinical Trials

37,506 Total Patients Enrolled

13 Trials studying Lymphoma

158 Patients Enrolled for Lymphoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this trial still inviting new participants?

"Based on the data listed in clinicaltrials.gov, this investigation is still recruiting suitable participants. The trial was first advertised on April 16th 2021 and has seen recent changes as of April 21st 2022."

Answered by AI

How much risk is associated with Glucarpidase administration?

"Glucarpidase has a security rating of 2, as evidence from Phase Two trials suggests its safety but not necessarily efficacy."

Answered by AI

What is the current enrollment size for this investigation?

"Affirmative. As per the information on clinicaltrials.gov, this trial is still looking for volunteers; it was initially announced on April 16th 2021 and edited most recently on April 21st 2022. 30 participants are needed from one particular site to complete the study."

Answered by AI

What additional research efforts have been utilized to investigate Glucarpidase?

"Presently, there are 6 Glucarpidase studies that have been initiated and 0 of them are in the last phase. Out of 20 trial sites across the country, most of them can be found in New york City."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma

2021. "HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04668768.