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Chemotherapy, Radiation, and Bone Marrow Transplant for Non-Hodgkin's Lymphoma
Phase 2
Waitlist Available
Research Sponsored by St. Luke's Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Performance status: CALGB 0-2 Karnofsky 70-100%
Pulmonary: Pulmonary function tests (DLCO and spirometry) greater than 60% predicted
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well high-dose etoposide and cyclophosphamide plus total-body irradiation followed by bone marrow transplantation works in treating patients with relapsed or refractory non-Hodgkin's lymphoma.
Who is the study for?
This trial is for patients with Non-Hodgkin's Lymphoma that hasn't responded to initial treatment. Participants must have a confirmed relapse, no tumor in their bone marrow, and can't have worsening cancer in previously treated areas. It's not for those classified under the new 'indolent' or 'aggressive' lymphoma terms.Check my eligibility
What is being tested?
The study tests high-dose etoposide and cyclophosphamide chemotherapy combined with total-body irradiation followed by bone marrow transplantation to see if this approach is more effective in treating relapsed or refractory Non-Hodgkin's Lymphoma.See study design
What are the potential side effects?
Potential side effects include damage to organs from radiation, immune system suppression leading to increased infection risk, nausea, hair loss from chemotherapy, and complications related to bone marrow transplant like graft-versus-host disease.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am mostly active and can care for myself.
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My lung function tests are above 60% of what's expected.
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My bone marrow biopsy is normal, with no signs of cancer.
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My kidney function is normal, with a creatinine clearance rate of at least 60 mL/min.
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My diabetes is under control.
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My scans show I have enlarged lymph nodes larger than 2 cm.
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I am 16 years old or older.
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I do not have an active stomach ulcer.
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I do not have any ongoing infections.
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I do not have serious organ problems not caused by lymphoma.
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I have no cancer other than treated early-stage cervical, basal, or squamous cell skin cancer.
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My liver function tests are within normal limits and I don't have hepatitis B.
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My non-Hodgkin's lymphoma came back or didn't respond after my first chemotherapy.
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My previously treated cancer area has not worsened.
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My heart's pumping ability is normal, and I don't have severe heart problems.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
St. Luke's Medical CenterLead Sponsor
12 Previous Clinical Trials
208,491 Total Patients Enrolled
Robert F. Taylor, MDStudy ChairSt. Luke's Medical Center
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am mostly active and can care for myself.My lung function tests are above 60% of what's expected.I have not received high doses of cyclophosphamide.My bone marrow biopsy is normal, with no signs of cancer.My kidney function is normal, with a creatinine clearance rate of at least 60 mL/min.My diabetes is under control.I have not received high doses of etoposide.My scans show I have enlarged lymph nodes larger than 2 cm.I am 16 years old or older.I do not have an active stomach ulcer.I have not had radiation therapy to my liver or lungs.I do not have any ongoing infections.I haven't had chemotherapy in the last 4 weeks.I have had radiotherapy before, but within safe dose limits.I do not have serious organ problems not caused by lymphoma.I have no cancer other than treated early-stage cervical, basal, or squamous cell skin cancer.I don't have any serious health or mental conditions that would stop me from joining the study.My liver function tests are within normal limits and I don't have hepatitis B.I have not had any previous salvage therapy.My non-Hodgkin's lymphoma came back or didn't respond after my first chemotherapy.I am encouraged to have a biopsy of my lymph nodes to confirm relapse.My previously treated cancer area has not worsened.My heart's pumping ability is normal, and I don't have severe heart problems.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Has this medication received FDA clearance?
"There is early clinical data supporting the safety of this treatment, but no evidence yet to suggest that it is effective. Consequently, it received a score of 2."
Answered by AI
Are people currently being signed up for this experiment?
"No, this particular clinical trial is not recruiting patients currently. Although, there are a total of 1792 other clinical trials that are enrolling individuals right now. The original posting date for this inactive study was March 1st, 1990 and the most recent edit was on December 17th, 2013."
Answered by AI
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