Treatment for Lymphoma

Ottawa Regional Cancer Centre - Civic Campus, Ottawa, Canada
18 - 65
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether a combination of drugs can be used to treat lymphoma.

See full description

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

1 Treatment Groups


This trial involves 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

Ottawa Regional Cancer Centre - Civic Campus - Ottawa, Canada

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. You must have received 1 prior treatment for Lymphoma. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
DISEASE CHARACTERISTICS: Histologically confirmed intermediate- or high-grade non- Hodgkin's lymphoma of the following histologies: Follicular, predominantly large cell Diffuse small cleaved cell Diffuse mixed, small and large cell Diffuse large cell Large cell, immunoblastic Lymphoblastic Small noncleaved cell Disease has relapsed following or is resistant to primary anthracycline-containing combination chemotherapy Objective response to salvage DHAP chemotherapy required Ineligible for bone marrow transplantation
PATIENT CHARACTERISTICS: Age: 18 to 64 Performance status: Zubrod 0 or 1 Hematopoietic: ANC at least 1,500 Platelets at least 140,000 Hb at least 10 g/dl Hepatic: Bilirubin less than 1.5 mg/dl (26 micromoles/liter) SGOT less than 4 x normal Renal: Creatinine less than 1.5 mg/dl (133 micromoles/liter) Cardiovascular: LVEF greater than 50% No life-threatening arrhythmia by EKG No uncontrolled hypertension Pulmonary: FEV, FVC, and DLCO greater than 50% of predicted Other: No uncontrolled diabetes No other uncontrolled medical condition No history of second malignancy except: Nonmelanomatous skin cancer Carcinoma in situ Effective contraception required of fertile women
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Prior anthracycline-containing combination chemotherapy required Prior salvage DHAP chemotherapy required Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: Not specifie

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can lymphoma be cured?

Add answer

With proper chemotherapy (with or not in remission), most patients are normal and healthy again. These patients still need follow-up, but it is possible that lymphoma can be cured. After complete remission and a relapse-free interval of at least 3 years, the chance of cure is good. But if there remain other diseases at the time of the relapse, there will most likely be another relapse.

Unverified Answer

What are the signs of lymphoma?

Add answer

In general, lymphoma often features B-symptoms. These can include difficulty in breathing or talking, a rapid heartbeat, loss of appetite, weight loss, swollen lymph nodes in the neck, chest or back. These can also be present in other forms of cancer but are more characteristic of lymphoma than other malignancies. Cancer can also cause bone lesions to be found, but these can also occur in other diseases. Lymphomas can also appear in certain types of blood tests. Recent findings of a full biopsy may be inconclusive. Cancer may also cause fatigue or poor concentration, or a feeling of loss of interest in activities that utilized the body.

Unverified Answer

What causes lymphoma?

Add answer

The epidemiology of lymphoma is very similar to that of many other common cancers. The risk of developing lymphoma increases with age and, in many communities, appears to be higher among men than women. A previous diagnosis of leukemia, lymphoma or myeloma significantly increases the risk of developing further lymphoma. Exposure to ionizing radiation, in particular to the head and neck region, is also an important risk factor. Non-Hodgkin lymphoma and a B-cell lineage lymphoma seem to be significantly associated with tobacco use. Hodgkin lymphoma is significantly associated with alcohol consumption, especially heavy drinking. Other lifestyle characteristics appear inconclusive, including body mass index, body fat distribution, and physical activity.

Unverified Answer

How many people get lymphoma a year in the United States?

Add answer

About 1,000 new cases a year in the USA are attributable to primary B-Cell lymphoma, which will have been more than a tenth those due to HL in 1992. This underscores the need for better information to be gathered about primary B-Cell lymphomas, since these lymphomas are difficult to diagnose and treat and have poorer treatment responses than HL is. The disparity between the incidence rates for HL and primary B-Cell lymphomas has the potential to skew our present data on the incidence of all lymphomas in the United States.

Unverified Answer

What is lymphoma?

Add answer

Symptoms of lymphoma are similar to those of pneumonia. A complete history and physical examination are necessary to help diagnose the specific type of lymphoma. Treatment includes the use of chemotherapy, radiation, or surgery.\n

Unverified Answer

What are common treatments for lymphoma?

Add answer

Most lymphomas are treated with radiation or chemotherapy. In recent years, rituximab has proven effective for some types of lymphomas. Stem cell transplantation therapy has also been recommended for more serious cases and lymphoma proactively.

Unverified Answer

Have there been any new discoveries for treating lymphoma?

Add answer

There was a search of all the studies done that have been published since then on the treatment of lymphoma in order to compile the key questions which to search for further evidence and answer. This resulted in 20 key questions, 13 of which were answered in literature. One key question was new types and dosage of agents to be used for lymphoma treatment. Other key questions include: is the combination of new agents used for lymphoma treatment more effective than single agents; the optimum chemotherapy for Hodgki’s lymphoma; and combination chemotherapy with or without new anti-viral agents for treating all types of lymphomas (Hodgkin’s lymphoma, follicular lymphoma, and diffuse lymphoma).

Unverified Answer

What is the average age someone gets lymphoma?

Add answer

In the U.S., the highest incidence of non-Hodgkin lymphoma occurs before the age of 40 in men but in women after the age of 50. This is likely due to lower rates of smoking, presumably cigarette-associated causes of nasopharyngeal cancer in men.

Unverified Answer

How serious can lymphoma be?

Add answer

Lymphomas are usually very serious and even if treated early, the overall outlook for patients is poor unless they receive more aggressive treatment later on. It is important to treat early rather than late, but then the patient should still be kept on a very regular follow-up, especially if the treatment consisted of chemotherapy and/or radiotherapy. A recent guideline from the UK on lymphoma from the ESCC published in 2013 recommends treating every suspected lymphoma in early stage (Stages I, II, and III but there is no definite answer if it should be Stages I and II in all circumstances as such a disease has never responded to the recommended treatments and the life expectancies are poor~.

Unverified Answer

How does treatment work?

Add answer

The prognosis of classical Hodgkin lymphoma is poor. Nevertheless, about half the patients can be spared from death due to a complete remission. Most will experience excellent quality of life while on treatment. The best way to preserve quality of life involves early and frequent assessment of patients and a close follow-up of the disease during treatment and especially in the long term.

Unverified Answer

Is treatment safe for people?

Add answer

There is currently little evidence-based evidence about the safety of treating people with lymphoma. There may also be safety issues not observed in an experimental setting. It is important to discuss these uncertainties with patients before treatment is advised or with treatment decisions.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Lymphoma by sharing your contact details with the study coordinator.