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Antineoplaston

Antineoplaston therapy for Lung Cancer

Phase 2
Waitlist Available
Led By Stanislaw R. Burzynski, MD, PhD
Research Sponsored by Burzynski Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

Current therapies for Stage IV or Recurrent Lung Cancer provide very limited benefit to the patient. The anti-cancer properties of Antineoplaston therapy suggest that it may prove beneficial in the treatment of Stage IV or Recurrent Lung Cancer. PURPOSE: This study is being performed to determine the effects (good and bad) that Antineoplaston therapy has on patients with Stage IV or Recurrent Lung Cancer.

Eligible Conditions
  • Lung Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2014 Phase 2 trial • 34 Patients • NCT00003458
79%
Hypokalemia
71%
Fatigue (asthenia, lethargy, malaise)
65%
Somnolence/depressed level of consciousness
62%
Vomiting
62%
Pain: Head/headache
44%
Nausea
44%
Hemoglobin
38%
Hyperglycemia
38%
Non-functional central venous catheter
35%
Leukocytes (total WBC)
35%
Hypernatremia
32%
Hypoglycemia
32%
Fever
29%
Lymphopenia
29%
SGPT
29%
Ataxia (incoordination)
29%
Proteinuria
26%
Diarrhea
24%
Edema/Fluid retention
24%
Hypercholesteremia
21%
SGOT
21%
Neutrophils/granulocytes (ANC/AGC)
21%
Central venous catheter infection
21%
Neuropathy: motor
18%
Alkaline phosphatase
18%
Dyspnea (shortness of breath)
18%
Urinary frequency/urgency
18%
Pain: Abdomen NOS
18%
Dizziness
18%
Tremor
18%
Seizure
15%
Cough
15%
Hemorrhage, pulmonary: Nose
15%
Hypophosphatemia
15%
Rash/desquamation
15%
Cushingoid appearance
15%
Uric acid, serum-high (hyperuricemia)
15%
Pain: Joint
15%
Speech impairment
15%
Infection (documented clinically): Upper airway NOS
12%
Bicarbonate, serum-low
12%
Pain: Extremity-limb
12%
Hypertriglyceridemia
12%
Constipation
12%
Opportunistic infection
12%
Hypocalcemia
12%
Hyponatremia
12%
Confusion
12%
Heartburn/dyspepsia
12%
GGT (gamma-Glutamyl transpeptidase)
12%
Pain: Neck
9%
Anorexia
9%
Hemorrhage, GU: Bladder
9%
Dry mouth/salivary gland (xerostomia)
9%
Albumin, serum-low (hypoalbuminemia)
9%
Hypercalcemia
9%
Hemorrhage, GU: Urinary NOS
9%
Petechiae
9%
Pruritus/itching
9%
Infection (documented clinically): Mucosa
9%
Hypomagnesemia
9%
Diplopia
9%
Pain: Muscle
9%
Pain: Back
9%
Rigors/chills
9%
Weight gain
6%
Incontinence, urinary
6%
Hemorrhage, CNS
6%
Platelets
6%
Bruising (in absence of Grade 3 or 4 thrombocytopenia)
6%
Pain: Chest wall
6%
Central Venous Catheter Infection
6%
Infection (documented clinically): Lung (pneumonia)
6%
Taste alteration (dysgeusia)
6%
Distension/bloating, abdominal
6%
Memory impairment
6%
Hypermagnesemia
6%
Pain: Middle ear
6%
Neuropathy: CN III Pupil, upper eyelid, extra ocular movements
6%
Neuropathy: cranial: CN VI Lateral deviation of eye
6%
Neuropathy: cranial: CN VII Motor-face; Sensory-taste
6%
Neuropathy: sensory
6%
Pain: Stomach
6%
Thrombosis/embolism - Central venous catheter
3%
Hematoma
3%
Infection (documented clinically): Skin (cellulitis)
3%
Hyperntremia
3%
Hydrocephalus
100%
80%
60%
40%
20%
0%
Study treatment Arm
Antineoplaston Therapy

Trial Design

1Treatment groups
Experimental Treatment
Group I: Antineoplaston therapyExperimental Treatment1 Intervention
Antineoplaston therapy (Atengenal + Astugenal) by IV infusion every four hours for at least 12 months. Study subjects receive increasing dosages of Atengenal and Astugenal until the maximum tolerated dose is reached.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Antineoplaston therapy (Atengenal + Astugenal)
1996
Completed Phase 2
~350

Find a Location

Who is running the clinical trial?

Burzynski Research InstituteLead Sponsor
64 Previous Clinical Trials
797 Total Patients Enrolled
Stanislaw R. Burzynski, MD, PhDPrincipal InvestigatorBurzynski Research Institute
61 Previous Clinical Trials
776 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Antineoplaston Therapy in Treating Patients With Recurrent or Stage IV Lung Cancer
1996. "Antineoplaston Therapy in Treating Patients With Recurrent or Stage IV Lung Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00003495.
~0 spots leftby May 2025
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