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Gabapentin for Lung Disease

Phase 3
Waitlist Available
Led By David Rice
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Undergoing pulmonary resection (includes metastasectomy as well as anatomic resections)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, up to 8 days
Awards & highlights

Study Summary

This trial aims to find out if gabapentin can help reduce the amount of pain medication needed after surgery, compared to placebo.

Eligible Conditions
  • Thoracic
  • Lung Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are having surgery to remove part or all of your lung.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, up to 8 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, up to 8 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The change in narcotic requirement following pulmonary resection with gabapentin is clinically significant when compared to the effect seen with placebo

Side effects data

From 2021 Phase 4 trial • 88 Patients • NCT03012815
2%
Allergic reaction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Gabapentin
Benzodiazepine

Trial Design

2Treatment groups
Experimental Treatment
Group I: PlaceboExperimental Treatment1 Intervention
designed to be compared with a study drug to learn if the study drug has any real effect
Group II: GabapentinExperimental Treatment1 Intervention
used as part of a multimodal pain regimen (combination of drugs used to control pain
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Gabapentin
2013
Completed Phase 4
~1550

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,965 Previous Clinical Trials
1,804,919 Total Patients Enrolled
David RicePrincipal InvestigatorM.D. Anderson Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Gabapentin prescribed to patients?

"Neuralgia, epilepsies, and postherpetic neuralgia are all pathological conditions that can be effectively managed using Gabapentin."

Answered by AI

Are there any other published papers that explore Gabapentin's effects?

"At the moment, there are 28 clinical trials underway for gabapentin. 11 of those trials are in the final stage (phase 3). Although many of the trials for gabapentin are based in Columbus, Ohio, there are actually 71 different locations running trials for this treatment."

Answered by AI

Are there any appointments available for this research program?

"Although this particular trial is not currently looking for patients, that doesn't mean there aren't other medical studies you could participate in. According to the most recent update on clinicaltrials.gov, this trial was last updated on 7/9/2022. Out of the 342 other clinical trials posted, many of them are actively recruiting patients right now."

Answered by AI

Is there a high potential for abuse with Gabapentin?

"Gabapentin has been studied in Phase 3 clinical trials, so it has some evidence of efficacy and multiple rounds of data confirming its safety. We rate it as a 3 on our safety scale."

Answered by AI

How many study participants are included in this clinical research?

"This study is no longer recruiting patients. It was initially posted on 7/31/2023 and last updated on 7/9/2022. However, there are 314 other trials recruiting patients with pulmonary diseases and 28 other trials enrolling patients that are taking Gabapentin."

Answered by AI

Who else is applying?

What state do they live in?
Texas
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)
2021. "Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05100160.
~0 spots leftby Apr 2025
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