Clonidine Injection for Sciatica (SERENITY CM Trial)

"This trial is open to adults aged 18 - 70."

"At present, 10 medical centres are actively enrolling patients. Locations include Kansas City, Overland Park and Winston-Salem among others. Choosing a site that is proximal to your residence can help reduce the travel burden of taking part in this trial."

"According to information readily accessible on clinicaltrials.gov, this medical trial is still open for enrollment. It was initially posted by the research team in June of 2023 and has seen its latest update on October 5th of the same year."

"After assessing all the information available, our team at Power rated Clonidine Micropellets Injection a 3 on safety due to its Phase 3 trial status. This signifies that there is both data supporting efficacy and repeated evidence of safety."

"Affirmative. According to clinicaltrials.gov, this research endeavor that was initially shared on June 19th 2023 is presently recruiting individuals. 340 participants are needed at 10 separate medical facilities and the study has recently been updated as of October 5th 2023."

"According to Sollis Therapeutics, Inc., the main outcome of this study will be quantifying Adverse Events from Baseline to Day 90. Furthermore, secondary outcomes that will be assessed include a comparison in Rescue medication consumption over 30 days, alteration in Average and Worst NRS pain scores from Day 90 post injection to month 12 post injection, and what percentage of participants experienced an impressive improvement in their pain level (30% or higher)."

"This clinical trial is looking for 340 individuals aged 18 to 70 who are experiencing sciatica. Applicants must also meet further criteria, such as having a pain score of between 6 and 9 on the 0-10 NRS scale that radiates below the knee in one dermatomal level, not having experienced significant relief from symptoms within two weeks prior to screening, being able to distinguish back and leg pains separately, and have had radicular pain symptoms present for 8-9 months at the time of screening. Furthermore, participants should not have received any mechanical interventions (e.g., physical therapy) before joining this trial."