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Antibiotic

D-cycloserine for Lower Back Pain

Phase 2
Waitlist Available
Led By Thomas J. Schnitzer, MD, PhD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 week
Awards & highlights

Study Summary

This trial is testing whether a drug called D-cycloserine can help people with chronic lower back pain.

Eligible Conditions
  • Lower Back Pain
  • Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Numeric Rating Scale (NRS) pain score 0-10; higher worse
Secondary outcome measures
12-Item Short Form Survey (SF-12)
Beck Depression Inventory (BDI)
Brain biomarkers (MRI)
+9 more

Side effects data

From 2016 Phase 4 trial • 8 Patients • NCT01833897
38%
sedation
25%
headache
13%
phosphenes
13%
hypomania
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ketamine and DCS Treatment

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: D-cycloserineExperimental Treatment1 Intervention
D-cycloserine 200 mg twice daily
Group II: PlaceboPlacebo Group1 Intervention
Placebo twice daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
D-cycloserine
2013
Completed Phase 4
~1060

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,586 Previous Clinical Trials
916,816 Total Patients Enrolled
United States Department of DefenseFED
865 Previous Clinical Trials
327,496 Total Patients Enrolled
Thomas J. Schnitzer, MD, PhDPrincipal Investigator - Northwestern University
Northwestern University

Media Library

D-cycloserine (Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT03535688 — Phase 2
Lower Back Pain Research Study Groups: D-cycloserine, Placebo
Lower Back Pain Clinical Trial 2023: D-cycloserine Highlights & Side Effects. Trial Name: NCT03535688 — Phase 2
D-cycloserine (Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03535688 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people fit the criteria to participate in this clinical trial?

"That is correct. The listing on clinicaltrials.gov does show that the trial administrators are still looking for patients to enroll. This particular trial was posted on March 30th, 2018 and updated January 6th, 2022. They are hoping to have 244 people participate at one location."

Answered by AI

Will D-cycloserine have any negative consequences for test subjects?

"D-cycloserine has received a safety score of 2. This is because, although there is evidence that it is safe, there have been no clinical trials demonstrating its efficacy."

Answered by AI

How does D-cycloserine usually help patients?

"D-cycloserine is often used to treat patients that have failed to respond to conventional therapies. It can also be an effective way of treating other conditions such as tuberculosis, extrapulmonary tuberculosis, and pulmonary tuberculosis."

Answered by AI

What other scientific papers feature D-cycloserine?

"Currently, there are 9 D-cycloserine studies underway. 2 of those trials have progressed to Phase 3 clinical testing. The great majority of these tests are taking place in Baltimore, MD; however, 23 sites across the country are running similar investigations."

Answered by AI

Are there any available vacancies for people who want to participate in this experiment?

"That is correct, the clinicaltrials.gov website has information indicating that this study is still looking for participants. The trial was originally posted on March 30th, 2018 and updated January 6th, 2022. They are currently seeking 244 patients from 1 site."

Answered by AI

Who else is applying?

What state do they live in?
California
Illinois
What site did they apply to?
Northwestern University Feinberg School of Medicine
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
2
3+

Why did patients apply to this trial?

At present I am refraining from taking any medication. I have low back pain and if anything helps I will try it and it may benefit someone else like me.
PatientReceived 1 prior treatment

How responsive is this trial?

Average response time
  • < 1 Day
Typically responds via
Email
Most responsive sites:
  1. Northwestern University Feinberg School of Medicine: < 24 hours
~29 spots leftby Apr 2025