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Alkylating agents
Chemotherapy for Liver Cancer
Phase 2
Waitlist Available
Research Sponsored by Matrix Pharmaceutical
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Cardiovascular: No coronary artery disease, No New York Heart Association class III or greater cardiac symptoms
Renal: Creatinine no greater than 1.3 times ULN OR Creatinine clearance at least 45 mL/min
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well cisplatin and epinephrine work when given directly into the tumor in treating patients with primary liver cancer.
Who is the study for?
This trial is for adults with primary liver cancer that can't be surgically removed. They should have a life expectancy of at least 4 months, no severe allergies to certain drugs, no history of encephalopathy or serious heart disease, and their liver function must meet specific criteria. Pregnant or nursing individuals are excluded.Check my eligibility
What is being tested?
The effectiveness of chemotherapy using cisplatin and epinephrine injected directly into the tumor is being tested in this Phase II trial. The goal is to see if this method kills more tumor cells in patients with unresectable primary liver cancer.See study design
What are the potential side effects?
Potential side effects may include reactions related to cisplatin such as kidney damage, hearing problems, nausea and vomiting; allergic reactions due to epinephrine including rapid heartbeat; and local effects at the injection site.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I do not have heart disease or severe heart symptoms.
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My kidney function, measured by creatinine levels or clearance, is within the required range.
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My cancer has not spread to major blood vessels.
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I have up to 3 tumors, none larger than 7 cm, and their total volume is under 200 cm3.
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My liver function tests are within acceptable ranges and I have mild to moderate liver impairment.
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My cancer is only in my liver.
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I can care for myself but may not be able to do active work.
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My liver cancer cannot be removed with surgery.
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I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
Matrix PharmaceuticalLead Sponsor
2 Previous Clinical Trials
120 Total Patients Enrolled
Richard D. Leavitt, MDStudy ChairMatrix Pharmaceutical
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had liver surgery before.I do not have heart disease or severe heart symptoms.I have not had biologic therapy for liver cancer.My kidney function, measured by creatinine levels or clearance, is within the required range.I have not had chemotherapy for liver cancer.My cancer has not spread to major blood vessels.I have not had hormone therapy for liver cancer.I have not had radiotherapy for liver cancer.I have up to 3 tumors, none larger than 7 cm, and their total volume is under 200 cm3.My cancer is only in my liver.I can care for myself but may not be able to do active work.My liver function tests are within acceptable ranges and I have mild to moderate liver impairment.My liver cancer cannot be removed with surgery.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there currently openings to join this scientific experiment?
"The information on clinicaltrials.gov affirms that this investigation is no longer recruiting participants since its last edit in December of 2013. Although the trial has been concluded, there are 251 other medical research programs that are currently enrolling individuals."
Answered by AI
What precautions are necessary to ensure patient safety during this procedure?
"The safety rating of this treatment is a 2 given that there are some data points indicating its security, but none demonstrating efficacy. This suggests it is in the second stage of clinical trials."
Answered by AI
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