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Thalidomide + Chemoembolization for Liver Cancer
Phase 2
Waitlist Available
Research Sponsored by National Center for Research Resources (NCRR)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
ECOG performance status > 2
No history of prior chemotherapy or biologic therapy for hepatocellular carcinoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial will test the safety and efficacy of the drug thalidomide in combination with chemoembolization in patients with inoperable liver cancer.
Who is the study for?
This trial is for adults with inoperable liver cancer who haven't had prior chemo or biologic therapy. They must have certain blood and organ function levels, not be pregnant or breastfeeding, use contraception, and have no other recent cancers except some skin or cervical ones. MRI should show specific tumor types in the liver.Check my eligibility
What is being tested?
The trial tests thalidomide's safety and effectiveness when given long-term alongside a procedure called chemoembolization (chemo directly to the liver plus blocking blood supply to tumors) using doxorubicin and collagen. It also looks at changes in certain proteins related to this cancer.See study design
What are the potential side effects?
Thalidomide may cause birth defects if taken during pregnancy; hence contraception is required. Other potential side effects include fatigue, dizziness, constipation, rash, nerve damage (neuropathy), low blood pressure (hypotension), fluid retention (edema), and blood clots.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I need assistance with my daily activities.
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I have never had chemotherapy or biologic therapy for liver cancer.
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My liver cancer cannot be removed with surgery.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
National Center for Research Resources (NCRR)Lead Sponsor
537 Previous Clinical Trials
317,016 Total Patients Enrolled
1 Trials studying Liver Cancer
33 Patients Enrolled for Liver Cancer
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I need assistance with my daily activities.I have never had chemotherapy or biologic therapy for liver cancer.I have no cancer history, except for treated skin or cervical cancer.My liver cancer cannot be removed with surgery.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are elderly individuals being included in the research study?
"To enroll in this medical trial, one must be aged 18 to 65. In addition, there are 17 trials for minors and 241 studies open to individuals older than 65 years old."
Answered by AI
To what extent could this treatment be detrimental to patients?
"The safety of this treatment was assigned a score of 2, as Phase 2 trials are known to provide some data confirming its security but none on the efficacy."
Answered by AI
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