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Antimetabolite

Effectiveness of amifostine &high-dose combination chemotherapy in treating patients with AML or CML for Leukemia

Phase 2
Waitlist Available
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial is studying how well amifostine works in combination with high-dose chemotherapy in treating patients with acute myeloid leukemia or chronic myelogenous leukemia.

Eligible Conditions
  • Leukemia
  • Myelodysplastic Syndrome
  • Neutropenia
  • Drug Toxicity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effectiveness of amifostine and high-dose combination chemotherapy in treating patients with acute myeloid leukemia or chronic myelogenous leukemia

Trial Design

1Treatment groups
Experimental Treatment
Group I: Effectiveness of amifostine &high-dose combination chemotherapy in treating patients with AML or CMLExperimental Treatment3 Interventions
Treatment of Newly Diagnosed High Risk And Relapsed Acute Myeloid Leukemia and Blastic Crisis Chronic Myelogenous Leukemia With Ethyol and High-Dose Cytarabine + Mitoxantroni, followed by Maintenance Phase Using Low-Dose ARA-C, rhGM-CSF, Pentoxifylline, Ciprofloxacin, and Decadron
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
amifostine trihydrate
2005
Completed Phase 3
~1190
cytarabine
1997
Completed Phase 3
~10270
mitoxantrone hydrochloride
1997
Completed Phase 3
~3750

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,531 Total Patients Enrolled
2 Trials studying Leukemia
National Cancer Institute (NCI)NIH
13,660 Previous Clinical Trials
40,924,272 Total Patients Enrolled
1,513 Trials studying Leukemia
384,749 Patients Enrolled for Leukemia
Philip D. Bonomi, MDStudy ChairRush University Medical Center
1 Previous Clinical Trials
1 Trials studying Leukemia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can be accepted into this medical experiment?

"The criteria for inclusion in this clinical trial are myelodysplastic syndromes and age between 18-120. A total of 50 individuals will be admitted to the study."

Answered by AI

Are there currently any openings for volunteers in this medical experiment?

"According to the clinicaltrials.gov records, this investigation is not presently seeking participants. Initially posted on April 1st 1998 and last updated on April 20th 2021, no fresh candidates are being sought by this trial at present; however there exist 2835 other studies actively recruiting patients right now."

Answered by AI

Does this medical trial permit those aged 45 and up to participate?

"The eligibility requirements for this research project include a minimum age of 18 and a maximum age of 120. There are 792 trials in which those younger than 18 can participate, alongside 2147 studies available to individuals that exceed 65 years old."

Answered by AI

Does the Food and Drug Administration currently endorse this treatment?

"Our internal assessment at Power deemed the treatment's safety to be a 2 as this is only Phase 2 and there are no studies reinforcing efficacy yet."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Amifostine & High-Dose Combination Chemotherapy in Treating Patients With Acute ML or CML
2001. "Amifostine & High-Dose Combination Chemotherapy in Treating Patients With Acute ML or CML". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00003407.
~0 spots leftby Apr 2025
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