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Peripheral Blood Stem Cell Transplantation for Chronic Myelogenous Leukemia
Study Summary
This trial is studying how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer.
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
Will this research be conducted with adult patients only?
"Children as young as one year old and adults up to 75 years of age may be eligible for this clinical trial, based on the inclusion criteria. There are 1702 other studies being conducted for patients under 18 and 6172 trials available for seniors."
How many people have been recruited for this clinical trial?
"This study is not admitting new patients at the moment. However, if you are seeking other studies, there are 6568 trials actively recruiting participants with thalassemia and 928 trials for Peripheral Blood Stem Cell Transplantation that may have open enrollment."
Are patients being recruited for this research project at present?
"This trial is not presently seeking participants anymore. The study was originally posted on 12/7/2017 and was most recently updated on 9/14/2022. If you are exploring for other studies, there are currently 6568 trials actively enrolling participants with thalassemia and 928 studies for Peripheral Blood Stem Cell Transplantation actively admitting participants."
Could you please elaborate on the risks associated with Peripheral Blood Stem Cell Transplantation?
"This treatment, while still in Phase 2 trials, has shown some promise in terms of safety. However, as it is still in the early stages of testing, there is no data yet supporting its efficacy."
What is the history of involving Peripheral Blood Stem Cell Transplantation in clinical trials?
"There are 928 clinical studies related to Peripheral Blood Stem Cell Transplantation currently underway. Of those, 165 are in Phase 3. The majority of trials for this treatment are based in Philadelphia, Pennsylvania; however, there are 28613 locations running trials for this treatment worldwide."
What disorders does Peripheral Blood Stem Cell Transplantation commonly alleviate?
"While Peripheral Blood Stem Cell Transplantation is most often used to treat multiple sclerosis, it can also be an effective intervention for mixed-cell type lymphoma, leukemia, myelocytic, acute, and retinoblastoma."
Could I join the ranks of this clinical trial's participants?
"Up to 31 individuals aged 1 year or older who currently have thalassemia are eligible for this trial. Along with meeting the age criteria, patients must also have a left ventricular ejection fraction > 40%, a Karnofsky (adult) or Lansky (for =< 16 years) performance status >= 60%. Additionally, the recipient should not have any HLA antibodies to potential donors. If the patient does have HLA antibodies, an alternative donor is preferred; though if there are no suitable alternative donors, the anti-HLAt antibodies can be depleted per transplant service guidelines. Any disease that is considered transplant eligible per TCT"
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