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Fluid Management

Protocol-based Fluid Management for Critical Illness (Probe-Fluid Trial)

N/A
Recruiting
Research Sponsored by Centre hospitalier de l'Université de Montréal (CHUM)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Admitted to the ICU
Age ≥ 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from randomization through day 90
Awards & highlights

Probe-Fluid Trial Summary

This trial tested a fluid management protocol to help critically ill patients receiving kidney replacement therapy. It aimed to stop fluid buildup and balance fluid levels.

Who is the study for?
This trial is for adults over 18 in the ICU with acute kidney injury (AKI) who meet specific criteria related to changes in serum creatinine or urine output. They must be starting kidney replacement therapy soon or have started it within the last 48 hours. People can't join if they're not expected to receive full support, might leave ICU soon, have severe burns, extreme sodium levels, ongoing fluid loss, or if their care team thinks the trial isn't right for them.Check my eligibility
What is being tested?
The study tests a protocol-based fluid management strategy against usual care in critically ill patients on kidney replacement therapy. The goal is to manage fluids more actively to prevent and treat fluid buildup by aiming for neutral or negative daily fluid balance.See study design
What are the potential side effects?
Potential side effects are not explicitly listed but may include complications from imbalanced fluid levels such as dehydration or overhydration which could affect blood pressure, heart function, and electrolyte balance.

Probe-Fluid Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am currently in the Intensive Care Unit.
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I am 18 years old or older.
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I am starting kidney replacement therapy soon or have started it within the last 2 days.

Probe-Fluid Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within +/- 7 days of the 90-day time point following randomization.
This trial's timeline: 3 weeks for screening, Varies for treatment, and within +/- 7 days of the 90-day time point following randomization. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cumulative fluid balance
Secondary outcome measures
Clinical: Death
Clinical: Hospital-free days
Clinical: ICU-free days
+15 more

Probe-Fluid Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Protocolized fluid removalExperimental Treatment1 Intervention
Group II: Usual careActive Control1 Intervention

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Who is running the clinical trial?

Centre hospitalier de l'Université de Montréal (CHUM)Lead Sponsor
365 Previous Clinical Trials
129,159 Total Patients Enrolled
Ron Wald, MDCM MPHStudy ChairUnity Health Toronto
2 Previous Clinical Trials
3,119 Total Patients Enrolled
William Beaubien-Souligny, MD PhDStudy ChairCHUM
1 Previous Clinical Trials
75 Total Patients Enrolled

Media Library

Protocol-based fluid management (Fluid Management) Clinical Trial Eligibility Overview. Trial Name: NCT05473143 — N/A
Kidney Transplant Research Study Groups: Protocolized fluid removal, Usual care
Kidney Transplant Clinical Trial 2023: Protocol-based fluid management Highlights & Side Effects. Trial Name: NCT05473143 — N/A
Protocol-based fluid management (Fluid Management) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05473143 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants still being admitted to this research program?

"Confirmed, the clinical trial is still actively recruiting participants. The study was originally posted on April 3rd 2023 and has been amended since then to reflect any changes."

Answered by AI

Is there an upper limit to the amount of participants signed on for this experiment?

"Affirmative, the clinical trial is currently accepting participants. The study was initiated on April 3rd 2023 and updated recently with a target recruitment of 150 patients from one medical centre."

Answered by AI
~47 spots leftby Sep 2024