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Protein Kinase Inhibitor
UCN-01 for Kidney Cancer
Phase 2
Waitlist Available
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Performance status: ECOG 0-2 OR Karnofsky 60-100%
Histologically or cytologically confirmed stage IV or unresectable stage III renal cell carcinoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well UCN-01 works in treating patients with kidney cancer that cannot be removed by surgery.
Who is the study for?
Adults with advanced kidney cancer that can't be removed by surgery or has spread (stage III/IV). They should have measurable tumors, normal liver and kidney function, no serious heart issues or uncontrolled illnesses. Participants must not be pregnant/nursing and agree to use contraception. No recent chemotherapy, radiotherapy, or nephrectomy; no more than two prior treatments for metastatic cancer.Check my eligibility
What is being tested?
The trial is testing the effectiveness of a chemotherapy drug called UCN-01 on patients with stage III or IV kidney cancer that cannot be surgically removed. The study aims to see if this drug can stop tumor cells from growing by interfering with their division.See study design
What are the potential side effects?
UCN-01 may cause side effects similar to other chemotherapy drugs which could include fatigue, nausea, vomiting, blood count changes increasing infection risk, liver enzyme alterations suggesting liver stress and potential allergic reactions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am mostly able to care for myself and remain up and about.
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My kidney cancer is at an advanced stage and cannot be surgically removed.
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My metastatic disease can be biopsied or treated with nephrectomy before starting the study treatment.
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My kidney function is normal or nearly normal.
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My heart is healthy with no significant diseases or symptoms.
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My liver tests are within normal limits.
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I do not have any current infections.
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I do not have diabetes that requires insulin.
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I am 18 years old or older.
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I do not have any lung problems that cause symptoms.
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I do not have cancer that has spread to my brain or spinal cord.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
University of California, San FranciscoLead Sponsor
2,499 Previous Clinical Trials
11,936,488 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,651 Previous Clinical Trials
40,932,930 Total Patients Enrolled
Brian I. Rini, MDStudy ChairUniversity of California, San Francisco
4 Previous Clinical Trials
847 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have not had radiation therapy to the chest area.It has been over 4 weeks since my kidney removal surgery.I have had 2 or fewer treatments for advanced kidney cancer.I am mostly able to care for myself and remain up and about.I do not have any heart problems causing symptoms.I do not have heart failure symptoms.My kidney cancer is at an advanced stage and cannot be surgically removed.My metastatic disease can be biopsied or treated with nephrectomy before starting the study treatment.My kidney function is normal or nearly normal.My heart is healthy with no significant diseases or symptoms.My liver tests are within normal limits.I will use birth control during and for 6 months after the study.I do not have any current infections.I do not have diabetes that requires insulin.I do not have any other serious illnesses that are not under control.I do not have an irregular heartbeat.I do not have unstable chest pain.I am 18 years old or older.I do not have any lung problems causing symptoms.I do not have serious heart artery problems.I do not have any lung problems that cause symptoms.I do not have cancer that has spread to my brain or spinal cord.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this therapeutic procedure secure and risk-free for participants?
"Our internal evaluation of this treatment's safety placed it at a 2. This is because, as we are in the second phase of trials, there have been some observations made about its risk profile but no confirmed efficacy data has been collected yet."
Answered by AI
Is this research trial currently recruiting participants?
"As per clinicaltrials.gov, this trial is no longer actively recruiting participants, having initially been posted in December 2002 and last modified on March 1st 2014. However, 423 other trials are presently looking for patients to join their studies."
Answered by AI
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