CLINICAL TRIAL

Curcumin for Kidney Diseases

Stage III
Recruiting · 18+ · All Sexes · Iowa City, IA

This study is evaluating whether curcumin may help improve vascular function and reduce inflammation in patients with chronic kidney disease.

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About the trial for Kidney Diseases

Eligible Conditions
Cognitive Decline · Renal Insufficiency, Chronic · Cognitive Dysfunction · Chronic Kidney Disease (CKD) · Kidney Diseases

Treatment Groups

This trial involves 2 different treatments. Curcumin is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Curcumin
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Placebo
OTHER

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Curcumin
FDA approved

Side Effect Profile for Curcumin

Curcumin
Show all side effects
21%
Gastrointestinal issues
6%
Tingling of tongue/mouth
6%
Warming or redness of face
6%
Eye redness, dryness, or swelling
3%
Headache
3%
Skin irritation
0%
Dry Mouth
Gastrointestinal issues
21%
Tingling of tongue/mouth
6%
Warming or redness of face
6%
Eye redness, dryness, or swelling
6%
Headache
3%
Skin irritation
3%
Dry Mouth
0%
This histogram enumerates side effects from a completed 2021 Phase 4 trial (NCT02494141) in the Curcumin ARM group. Side effects include: Gastrointestinal issues with 21%, Tingling of tongue/mouth with 6%, Warming or redness of face with 6%, Eye redness, dryness, or swelling with 6%, Headache with 3%.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
BMI<35 kg/m2
Able to give informed consent
CKD stage IIIB and IV
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Curcumin will improve 1 primary outcome and 2 secondary outcomes in patients with Kidney Diseases. Measurement will happen over the course of 12 months.

Cognitive function
12 MONTHS
NIH toolbox battery
12 MONTHS
Large artery stiffness
12 MONTHS
Aortic pulse wave velocity
12 MONTHS
Vascular endothelial function
12 MONTHS
Brachial artery flow-mediated dilation
12 MONTHS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can kidney diseases be cured?

Many CKD patients suffer from high levels of physical inactivity and malnutrition. CKD patients have an increased risk to develop type 2 diabetes and high blood pressure. Since recent studies have shown the potential of bone marrow to heal and replace tissue and body organs there is a focus on bone marrow cell treatment in CKD patients. These studies have shown the potential to treat CKD and improve patient prognosis. Bone marrow cells (BMC) that are a type of adult stem cell possess a unique ability (called "transdifferentiation") to give rise to specific cell types through cell-to-cell interaction (such as in embryonic development) and differentiation (an important part of the stem cell process).

Anonymous Patient Answer

What is kidney diseases?

Around 5% of Caucasians over 15 have kidney disease and almost half have a chronic kidney disease. Diabetes mellitus appears to be more common amongst people with kidney disease than without. There is a wide spectrum of kidney disease and this is very important because the underlying basis of kidney disease determines the therapeutic requirements of the underlying condition.\n

Anonymous Patient Answer

What are common treatments for kidney diseases?

There is no cure for chronic kidney diseases. Symptoms are managed with a medication and regular follow-up. When a chronic kidney disease worsens, a kidney replacement therapy is needed to replace the function that a kidney fails to provide.

Anonymous Patient Answer

How many people get kidney diseases a year in the United States?

By the end of 2018, at least 21% of men and women older than 65 years had had a kidney disease, and an additional 5 % had an acute kidney injury requiring dialysis or a need for a kidney transplant. Over 50% of men and 55% of women had some type of diabetes.

Anonymous Patient Answer

What causes kidney diseases?

Kidney diseases can be caused by a broad spectrum of clinical manifestations, including systemic inflammatory diseases, endocrine or autoimmune disorders, infections, metabolic or nutritional abnormalities, or genetic factors. Diagnostic workup is tailored to the suspected cause, rather than to the exact clinical presentation because symptoms often overlap.

Anonymous Patient Answer

What are the signs of kidney diseases?

Symptoms of kidney disease may include an enlarged, hard, and dull-sounding kidney, loss of appetite and nausea, feeling tired all day, shortness of breath, and joint pain. More advanced kidney failure may involve decreased level of consciousness, increased thirst, and frequent urination. Chronic kidney failure, on the other hand, may be accompanied by muscle weakness or bone pain.

Anonymous Patient Answer

Does curcumin improve quality of life for those with kidney diseases?

Results from a recent clinical trial underscore the importance of a healthy lifestyle, and the value of curcumin for controlling hypertension and improving the quality of life in patients with kidney diseases.

Anonymous Patient Answer

Is curcumin typically used in combination with any other treatments?

There is a good correlation between the results of clinical trials and those of animal studies. Furthermore, the curcumin is already being used in combination with many drugs, most notably with gemcitabine, a treatment which is also already approved in many countries. There are, however, concerns about the negative effects of curcumin on the liver, kidney and gastrointestinal tract (especially with high doses). The potential hazards with curcumin should be considered. Further studies should be performed, to ascertain which doses are safe and also which combinations might be most effective.

Anonymous Patient Answer

Who should consider clinical trials for kidney diseases?

Findings from a recent study shows a high prevalence of renal impairment among patients with CKD in a cohort of Italian general hospitals. More than two-fifths (68%) of patients fulfilled the entry criteria for a randomized controlled trial to treat CKD. To increase the enrolment rate, patients with mild chronic renal insufficiency at highest risk should be targeted and the necessity and advantages of clinical trials for CKD have to be re-evaluated.

Anonymous Patient Answer

What is the primary cause of kidney diseases?

A considerable share of the common CKD-related risk factors are modifiable, and their prevention would reduce the burden caused by CKD globally. However, the primary cause of CKD is still an unsolved question, even despite a number of large-scale epidemiological studies. A clearer understanding of the causes of CKD seems warranted before the appropriate action to reduce the burden of CKD can be assumed.

Anonymous Patient Answer

What is curcumin?

The anti-inflammatory profile of curcumin, along with its anti-angiogenesis and anti-oxidative properties, make it a potential therapeutic in renal diseases associated with angiogenesis. Further, its ability to promote the antiapoptotic phenotype of podocytes might lessen the progression of DN.

Anonymous Patient Answer

How does curcumin work?

Curcumin exerts a profound anticancer effect on prostate PC-3 and other cancer cell lines of varying histological origin. An increase in the expression of caspase and other apoptosis-related genes could potentially have contributed significantly to the anticancer properties of curcumin. Thus the results are an exciting proof of principle that shows that curcumin acts as a promising anticancer agent.

Anonymous Patient Answer
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