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Polyphenol

Curcumin for Chronic Kidney Disease

Phase 2
Waitlist Available
Research Sponsored by Diana Jalal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial will test whether curcumin can improve vascular function and cognitive function in patients with CKD by reducing oxidative stress and inflammation.

Who is the study for?
This trial is for adults who can consent, have moderate to severe chronic kidney disease (not the most advanced stages), and a BMI under 35. It's not for those who've eaten lots of curcumin or taken supplements recently, are pregnant or not using birth control, have very serious heart failure, recent hospital stays, current infections or recent heavy-duty immune system drugs.Check my eligibility
What is being tested?
The study tests if curcumin improves blood vessel function and reduces stiffness in arteries by tackling oxidative stress in patients with chronic kidney disease. It also looks at whether curcumin helps with brain functions like memory and thinking. Participants will either receive curcumin or a placebo without active ingredients.See study design
What are the potential side effects?
Curcumin is generally considered safe but may cause digestive upset like gas, bloating, diarrhea; yellow stool; headaches; rashes; and low blood sugar levels especially in people with diabetes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Vascular endothelial function
Secondary outcome measures
Cognition
Large artery stiffness

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CurcuminExperimental Treatment1 Intervention
Patients will receive curcumin (Lonvida) 2000 mg PO once a day
Group II: PlaceboPlacebo Group1 Intervention
Patients will receive placebo pill identical in appearance and taste to the supplement
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Curcumin
2017
Completed Phase 4
~1050

Find a Location

Who is running the clinical trial?

Stanford UniversityOTHER
2,387 Previous Clinical Trials
17,333,962 Total Patients Enrolled
University of Colorado, DenverOTHER
1,732 Previous Clinical Trials
2,143,495 Total Patients Enrolled
Diana JalalLead Sponsor
1 Previous Clinical Trials
25 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What other scientific investigations have been conducted on Curcumin?

"Curcumin, a natural compound found in the spice turmeric, is currently being trialed in 17 separate studies. 3 of these investigations are classified as Phase 3 trials. Most of the research for Curcumin is based out of Farmington Hills, Michigan; however, there are 21 total locations running clinical trials for this substance."

Answered by AI

Would I be able to join this medical study?

"The aim of this study is to enrol 88 individuals aged 45-74 who have a diagnosis of chronic kidney disease (CKD). In order to qualify, potential participants must also meet the following requirements: CKD stage IIIB and IV, BMI<35 kg/m2, Able to give informed consent."

Answered by AI

What is the FDA's official stance on curcumin?

"Curcumin has been found to be safe in Phase 2 trials, but more research is needed to support its efficacy."

Answered by AI

If an adult is not yet 50 years old, can they participate in this research?

"This particular clinical trial is testing a new medication for people aged 45 to 74. In contrast, there are 69 other trials currently underway for patients under 18 and 1038 medical studies involving seniors."

Answered by AI

Are people with the required medical conditions currently being accepted into this trial?

"That is correct. The listings on clinicaltrials.gov say that the trial is recruiting patients. This particular study was first posted on 1/30/2018, and the most recent update was 1/3/2022. They are looking for a total of 88 participants at one location."

Answered by AI

How many people will be included in this research project?

"Yes, that is correct. The clinicaltrials.gov website has information about this trial and it is looking for 88 participants at 1 location."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
Diana Jalal 2018. "Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03223883.
~12 spots leftby Apr 2025
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