Inhaled volatile general anesthesia for Depression

Phase-Based Progress Estimates
Stanford University, Stanford, CA
Depression+16 More
Anesthetic technique inhaled agent - Other
All Sexes
What conditions do you have?

Study Summary

To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.

Eligible Conditions

  • Depression
  • Nausea, Postoperative
  • Pain, Postoperative
  • Anaesthesia therapy
  • Surgery
  • Quality of Life (QOL)
  • Anesthesia Complications
  • Awareness, Anesthesia
  • Anesthesia Emergence Delirium
  • Anesthesia Morbidity
  • Surgery- Complications
  • Shift-Work Sleep Disorder

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Study Objectives

3 Primary · 1 Secondary · Reporting Duration: 11 months

11 months
Completeness of data collection
8 months
Proportion participating
Proportion receiving TIVA
Proportion receiving inhaled anesthesia

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Inhaled volatile general anesthesia
1 of 2
Propofol total intravenous anesthesia (TIVA)
1 of 2
Active Control

300 Total Participants · 2 Treatment Groups

Primary Treatment: Inhaled volatile general anesthesia · No Placebo Group · Phase 3

Inhaled volatile general anesthesia
ActiveComparator Group · 1 Intervention: Anesthetic technique inhaled agent · Intervention Types: Other
Propofol total intravenous anesthesia (TIVA)
ActiveComparator Group · 1 Intervention: Anesthetic technique Propofol TIVA · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 11 months

Trial Background

Michael Avidan, Prof of Anesthesiology
Principal Investigator
Washington University School of Medicine
Closest Location: Stanford University · Stanford, CA
Photo of Stanford University  1Photo of Stanford University  2Photo of Stanford University  3
1992First Recorded Clinical Trial
38 TrialsResearching Depression
768 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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You must be at least 18 years old.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.