Study Group for Infections
This study is evaluating whether Envarsus is as effective as Tacrolimus-IR in preventing BK virus infection.
See full descriptionAbout the trial for Infections
Treatment Groups
This trial involves 2 different treatments. Study Group is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Study Group will improve 4 primary outcomes and 1 secondary outcome in patients with Infections. Measurement will happen over the course of From baseline to 300 days.
Who is running the study
Principal InvestigatorPatient Q & A Section
Can infections be cured?
At present, there is no cure for infections. The therapy for infections could not be perfected because the bacteria are too small to be seen and controlled by the human eye, even at the smallest magnification. However, it is possible to reduce the frequency of severe infections of the respiratory and urinary tracts with antibiotics when taken intermittently during the infection. The main problem of the antibiotic prophylaxis is the resistance of pathogenic bacteria. Although most frequently pathogenic bacteria are sensitive to the antibiotic medications, they are still able to be resisted. The antibiotics are effective against gram-positive bacteria, but rarely against gram-negative bacteria.
How many people get infections a year in the United States?
The number of infections that affect the United States population is a huge number and continues to increase in its population and complexity. Most commonly reported diseases are viral disease due to one or more of the following: common cold, hepatitis, gastroenteritis, respiratory illness, influenza, meningitis, encephalitis, and meningococcal disease. Of all infections, foodborne illness accounts for over 50% of reported illness with nearly 2...3 million cases per year. Foodborne illnesses are likely the leading cause of illness among those who have recently traveled to or resided in the United States. Other leading illnesses that may affect the public should be recognized by patients as other illnesses may be co-existent in those cases.
What is infections?
From a medical perspective, infections are frequently a cause of death. Severe or life-threatening infections cause about 15% of all deaths in developing countries. More than 150 kinds of pathogens are involved in infections, which generally occur worldwide. Severe or life-threatening infections are most frequent among the elderly, the infirm, the injured, patients with compromised immune systems, and patients with diabetes or renal dysfunction. A wide range of treatments are available and have become available over the past few decades. One in four new cases of life-threatening infections is prevented annually by public health measures, vaccines, and medical therapies. More than 20 new and more effective drugs for infections are under development.
What causes infections?
Individuals with chronic inflammatory or other chronic conditions are at increased risk of infections. Immunocompromised people are particularly prone to infection. There are several risk factors that contribute to an increased risk of infections, including increased age and chronic disorders.
What are the signs of infections?
An accurate knowledge of the signs and symptoms, in addition to a good physical examination, often leads to the timely recognition of infections and helps to treat them. The main signs of infections are fever, headache, nausea, vomiting, weight loss and night sweats. Routine follow-up of these signs enables early diagnosis and treatment.
What are common treatments for infections?
Given the common causes of the infections and recommendations by the AHRQ, clinicians should be aware of the most common treatments and be prepared for those that are uncommon so as to minimize antibiotic use and minimize potential adverse effects.
What is the latest research for infections?
The current available research has proven that [SARS] is the strongest risk to patients, and [SARS], [MERS] are the strongest risks to health professionals. Currently, infections only related to [SARS] and [MERS] were found, but they have some important facts we should read about. There are few infectious agents to choose such as [HIV]. [Graft versus host disease] refers to [HSV] and [VZV]. [Tuberculosis\nis found]. There are others such as [leishmaniasis]. The pathogens [syphilis] and [HIV] are mostly studied and reported by experts from all around the world, and it can be found online.
What is study group?
Group allocation can be a source of bias, especially in studies where the intervention may differ from its placebo according to a number of confounders, such as sex, age, disease duration, or other variables of interest.
Have there been other clinical trials involving study group?
Clinical trials are conducted across the globe and new drug development involves an ever-growing number of investigational therapies. In a recent study, findings highlights the importance of well-conducted and well reported clinical trials with patients and, where indicated, clinicaltrials.gov.
Who should consider clinical trials for infections?
Patients can understand the importance of clinical trials for infectious diseases when they are informed that they can expect a new treatment that will help them feel safer and healthier. In addition, patients who learn that they will be participating in a clinical trial can anticipate personal benefits including a chance to receive the safest or most effective treatment available for their illness/disease. Clinicians can use clinical trial information to inform patients about the advantages and disadvantages of a new treatment option before they have a chance to decide for themselves.
Does study group improve quality of life for those with infections?
Results from a recent paper indicate a statistically significant increase in quality of life across both the treatment groups at the end of the course of treatment. The improvements found for several dimensions of HRQoL are likely to be clinically significant.
Have there been any new discoveries for treating infections?
We cannot say there is new information worth searching because our results are not definitive. This means that we could find new information, but we do not find it worth spending the time and energy it would take to search for information. Although we could not find any one particular new discovery, that doesn’t mean it isn’t there. More specifically, it means these results could be used in a clinical trial to further advance treatment for people with infections.