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Vasodilator

Treatment Group for Coronavirus (NOpreventCOVID Trial)

Phase 2
Waitlist Available
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 14 days
Awards & highlights

NOpreventCOVID Trial Summary

This trial will help researchers understand if inhaled nitric oxide can help protect healthcare workers from SARS-CoV-2.

Eligible Conditions
  • Coronavirus
  • Healthcare-Associated Infections

NOpreventCOVID Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~14 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
COVID-19 diagnosis
Secondary outcome measures
Positive SARS-CoV-2 rt-PCR test
Other outcome measures
Proportion of healthcare providers requiring quarantine
Total number of quarantine days

Side effects data

From 2021 Phase 4 trial • 519 Patients • NCT03081052
28%
Venous Thromboemolic DVT
13%
Venous Thromboembolic Other
11%
New Onset Atrial Fibrillation
9%
All Cause Mortality
6%
Arterial Thromboembolic CVA/Stroke
5%
Venous Thromboembolic PE
3%
Arterial Thromboembolic Mesenteric Ischemia
2%
Arterial Thromboembolic Myocardial Infarction
2%
Upper GI Bleed
1%
Lower GI Bleed
100%
80%
60%
40%
20%
0%
Study treatment Arm
Lung Transplant With iNO
Lung Transplant With iEPO
Heart Transplant & LVAD Implantation With iNO
Heart Transplant & LVAD Implantation With iEPO

NOpreventCOVID Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Treatment GroupExperimental Treatment1 Intervention
Inhaled NO (160 ppm) before and after the work shift. Daily monitoring of body temperature and symptoms. SARS-CoV-2 RT-PCR test if fever or COVID-19 symptoms.
Group II: Control GroupActive Control1 Intervention
Daily monitoring of body temperature and symptoms. SARS-CoV-2 RT-PCR test if fever or COVID-19 symptoms.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,931 Previous Clinical Trials
13,198,421 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies available for individuals to join this trial?

"Clinicaltrials.gov affirms that this medical trial, which was initially publicized on April 7th 2020 and last updated on November 8th 2022, is currently not recruiting new participants. However, there are a myriad of other studies enrolling patients at this time - 854 to be precise."

Answered by AI

How extensive is the current enrolment in this trial?

"Unfortunately, this experiment is not currently onboarding patients. Initially posted on April 7th 2020 and lastly edited on November 8th 2022, it has been superseded by other research endeavors. Specifically, there are presently over 800 trials looking into cross infection while 21 clinical studies explore Treatment Group options."

Answered by AI

Is the upper age limit for this trial beyond 40 years?

"All individuals who are 18 years and older, but below 99 years of age can apply for this study."

Answered by AI

What precedent has been set through Treatment Group's previous clinical trials?

"Presently there are 21 trials researching Treatment Group, 8 of which are in the advanced Phase 3 stage. Anchorage, Alaska functions as the hub for these investigations; however, 97 other places worldwide have active clinical experiments."

Answered by AI

How reliable is Treatment Group in regard to patient security?

"The safety of Treatment Group has been evaluated as a 2, since this is a Phase 2 trial. Thus far there are indications that it is safe to use, but no data confirming its efficacy."

Answered by AI

What criteria must be fulfilled to partake in this clinical trial?

"This clinical trial seeks to enrol 24 patients who have had contact with SARS-CoV-2 and are at least 18 years of age. Applicants should be regularly exposed to the virus, having worked with infected individuals for a minimum of three days each week."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
NO Prevention of COVID-19 for Healthcare Providers
Lorenzo Berra, MD 2020. "NO Prevention of COVID-19 for Healthcare Providers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04312243.
All > Covid
~5 spots leftby Apr 2025
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