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Xanthine Oxidase Inhibitor

Allopurinol for Type 2 Diabetes

Phase 2
Waitlist Available
Led By Camila Manrique Acevedo, MD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 6 months (final). the goal is to assess changes from baseline when compared to final time point.
Awards & highlights

Study Summary

This trial will test three interventions to see if they can improve pulse wave velocity in men and women with type 2 diabetes. The first group will take allopurinol to reduce serum uric acid, the second group will restrict dietary fructose, and the third group will restrict dietary fructose and also achieve a caloric deficit.

Eligible Conditions
  • Type 2 Diabetes
  • High Uric Acid

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 6 months (final). the goal is to assess changes from baseline when compared to final time point.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 6 months (final). the goal is to assess changes from baseline when compared to final time point. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Carotid Femoral Pulse Wave Velocity (cfPWV)
Secondary outcome measures
Brachial Artery Flow Mediated Dilation (FMD)
Insulin-stimulated Leg Blood Flow

Side effects data

From 2019 Phase 3 trial • 530 Patients • NCT02017171
16%
Rash
12%
Upper respiratory tract infection
10%
Hypoglycaemia
7%
Nasopharyngitis
6%
Urinary tract infection
6%
Influenza like illness
6%
Sinusitis
6%
Diabetic ketoacidosis
5%
Pain in extremity
4%
Bronchitis
3%
Acute myocardial infarction
2%
Osteomyelitis
2%
Abortion spontaneous
1%
Diarrhoea
1%
Myocardial infarction
1%
Cardiac failure congestive
1%
Diabetic gastroparesis
1%
Chest pain
1%
Pancreatitis acute
1%
Asthma
1%
Coronary artery disease
1%
Gastrointestinal haemorrhage
1%
Pneumonia
1%
Cardiac arrest
1%
Hyperglycaemia
1%
Death
1%
Cellulitis
1%
Staphylococcal infection
1%
Road traffic accident
1%
Renal failure acute
1%
Pregnancy
1%
Skin ulcer
1%
Amputation
1%
Hyperemesis gravidarum
1%
Angina unstable
1%
Impaired gastric emptying
1%
Cerebrovascular accident
100%
80%
60%
40%
20%
0%
Study treatment Arm
Allopurinol
Placebo

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Low-fructose diet, isocaloricExperimental Treatment1 Intervention
Subjects assigned to this arm of the study will consume for 6 months a diet low in fructose while maintaining baseline body weight.
Group II: Low-fructose diet, hypocaloricExperimental Treatment1 Intervention
Subjects assigned to this arm of the study will consume for 6 months a diet low in fructose with a 500 Calorie energy reduction.
Group III: AllopurinolExperimental Treatment1 Intervention
Subjects assigned to this arm of the study will be treated for 6 months with allopurinol (max dose 300 mg)
Group IV: PlaceboPlacebo Group1 Intervention
Subjects assigned to this arm will receive placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Allopurinol
FDA approved

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
361 Previous Clinical Trials
627,960 Total Patients Enrolled
Camila Manrique Acevedo, MDPrincipal InvestigatorUniversity of Missouri-Columbia
2 Previous Clinical Trials
209 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
Camila Manrique, MD 2018. "Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03648996.
~5 spots leftby Apr 2025
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