This trial is evaluating whether Sodium Nitrite will improve 1 primary outcome and 4 secondary outcomes in patients with Heart Failure. Measurement will happen over the course of 10 weeks (i.e. the 10th week of placebo vs 10th week of nitrite)..
This trial requires 21 total participants across 2 different treatment groups
This trial involves 2 different treatments. Sodium Nitrite is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"The most probable cause is an inadequate blood flow. Hypertension is usually due to the vascular wall being stiff and thus resisting blood flow. This causes resistance, and in turn pressures, to increase in order to counterbalance the increase in resistance. A pulmonary arterial stenosis is the most probable condition that causes this." - Anonymous Online Contributor
"The improvement in pulmonary hemodynamics and vascular pathophysiology is related to an improvement in heart function and pulmonary histological evaluation. The reduction in right heart pressure and pulmonary hypertension could allow patients to go out of hospital." - Anonymous Online Contributor
"The number of Americans who develop non-communicable diseases like hypertension, chronic obstructive pulmonary diseases, ispaht-associated pulmonary diseases, and various forms of cancer by the year 2030 is likely to increase if public health is not addressed immediately. If public health is not addressed, then there is a high possibility that the number of people with these chronic diseases in the United States may reach the levels of health problems caused by HIV/AIDS or other chronic lung diseases. The United States will then face a significant public health problem on a national level. At this point in the health care system, we can not afford to ignore the burden of chronic lung disease on the nation." - Anonymous Online Contributor
"The clinical features of hypertension are diverse. While there are many signs that can be noticed in general, some signs are very specific for this condition." - Anonymous Online Contributor
"Results from a recent clinical trial of research support the use of anti-hypertensive drugs. In some cases, beta blockers will be prescribed in the absence of first-line treatment. In case of resistance to conventional monotherapy, ACE inhibitors will be the therapeutic choice in addition to beta blockers. There are also non-pharmacological options like pulmonary rehabilitation to improve the quality of life of these patients." - Anonymous Online Contributor
"Patients with [pulmonary hypertension](https://www.withpower.com/clinical-trials/pulmonary-hypertension) usually experience right ventricular hypertrophy secondary to their hypertension, but occasionally develop left ventricular hypertrophy. Pulmonary hypertension also leads to decreased exercise capacity, fatigue, and shortness of breath. There is no one definitive test that determines a specific diagnosis. Treatment often entails treating hypertension, or some combination of medications and diuretics. Medications include beta blocker or prostacyclin in certain cases. These treatments can often help the pulmonary system, especially when combined with a diuretic such as furosemide. Occasionally, in some cases, surgery can be performed on the patient's lungs." - Anonymous Online Contributor
"It appears that family history of hypertension and/or pulmonary hypertension (pulmonary vascular disease in some cases) is associated with an increased risk of death from cardiovascular causes in black individuals. Black individuals with a family history of hypertension (pulmonary hypertension in some cases) are particularly susceptible to the disease." - Anonymous Online Contributor
"The data suggest that sodium nitrite may result in significant elevation of the blood pressure in people with hypertension. The data are of particular value in an environment of increasing hypertension-related health care utilization." - Anonymous Online Contributor
"Overall, hypertension occurs more commonly in older age groups, with a small rise occurring in the 6th, 9th, and 11th decades of life. Hypertension in persons of all ages can lead to long-term morbidity and disability with serious health consequences including heart failure and dementia." - Anonymous Online Contributor
"The meta-analysis of this meta-analysis provides convincing evidence that the combination of sodium nitrite and simvastatin in an initial 4-week treatment has greater benefits than simvastatin alone." - Anonymous Online Contributor
"Sodium nitrite may reduce the risk of pulmonary haemorrhagic events that could be prevented by pulmonary hypertension prophylaxis. It seems it does by improving the vasodilation and by protecting red blood cells against oxidative damage." - Anonymous Online Contributor
"According to this investigation, there is no consensus regarding the most effective treatment of pulmonary arterial hypertension in a clinical context. The treatment of pulmonary arterial hypertension is highly complex and a rational approach that takes into account the severity and heterogeneity of the disease is necessary. The present study highlights the most up to date available data (new and old) supporting the use of different treatment combinations to improve the therapeutic efficacy of the treatment of pulmonary arterial hypertension in a clinical context." - Anonymous Online Contributor