CLINICAL TRIAL

QUARTET LDQT for Hypertension

Recruiting · 18+ · All Sexes · Bloomingdale, IL

Efficacy and Safety of a Quadruple Ultra-low-dose Treatment for Hypertension

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About the trial for Hypertension

Treatment Groups

This trial involves 2 different treatments. QUARTET LDQT is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
QUARTET LDQT
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Candesartan
DRUG

Eligibility

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
People with high blood pressure who have not received treatment in the last 12 weeks and have blood pressure readings of 140-179 mmHg for systolic blood pressure or 90-109 mmHg for diastolic blood pressure, or have been taking medication to control their blood pressure but have readings of 130-159 mmHg for systolic blood pressure or 85-99 mmHg for diastolic blood pressure, are likely to benefit from taking medication to further lower their blood pressure. show original
1) People who have not received treatment before, 2) People who are not currently taking treatment, or 3) People who are currently taking a single blood pressure lowering drug at any dose. show original
Adults (≥18 years)
No matter if you are a Spanish or English speaker, you can learn how to say "I love you" in the other language show original
The patient has documentation of hypertension or high blood pressure in the past 24 months from a general practitioner, pharmacist, or health care professional. show original
The text states that research grade blood pressure measurements should have a baseline mean of greater than or equal to 115 mmHg for SBP and greater than or equal to 60 mmHg for DBP. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 24 hours at 12 week follow up
Screening: ~3 weeks
Treatment: Varies
Reporting: 24 hours at 12 week follow up
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 24 hours at 12 week follow up.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether QUARTET LDQT will improve 8 secondary outcomes and 18 other outcomes in patients with Hypertension. Measurement will happen over the course of 6 weeks.

Change in Mean Systolic Blood Pressure
6 WEEKS
Mean change (from baseline) in automated office systolic blood pressure adjusted for baseline values.
6 WEEKS
Proportion of patients with adverse event free hypertension control
12 WEEKS
Proportion of patients with adverse event free hypertension control (percent with SBP < 130 mmHg and DBP <80 mmHg).
12 WEEKS
Mean Change in Blood Urea Nitrogen
12 WEEKS
Mean change (from baseline) in continuous blood urea nitrogen.
12 WEEKS
Mean Systolic Blood Pressure
12 WEEKS
Mean automated office systolic blood pressure adjusted for baseline values.
12 WEEKS
Mean Change in Serum Sodium
12 WEEKS
Mean change (from baseline) in continuous serum sodium.
12 WEEKS
Health-related quality of life
12 WEEKS
Mean change (from baseline) in health-related quality of life using PROMIS Global Health instrument.
12 WEEKS
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Who is running the study

Principal Investigator
M. H.
Prof. Mark Huffman, Professor of Medicine and Global Health Center Co-Director
Washington University School of Medicine

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should consider clinical trials for hypertension?

Approximately one half of the hypertensives seen in primary care meet the trial entry criteria. The higher percentage of those that would qualify who were identified in this study reflects the fact that our study found many more patients with hypertension than would be detected in the average general practice population.

Anonymous Patient Answer

How many people get hypertension a year in the United States?

Hypertension was highly prevalent in this population sample. The prevalence of hypertension increases with age. The prevalence of hypertension is higher, although not yet statistically significant, among blacks and non-Hispanic whites than among Hispanics and Hispanics of Anglo/White race.

Anonymous Patient Answer

What is hypertension?

Hypertension is a common disease that, due to the fact that the disease is age-related, is a long-term problem that can last up to the age of over 70 years.\n

Anonymous Patient Answer

What are common treatments for hypertension?

A number of treatments options for hypertension are common to the general population. These include both medications (i.e. ACE inhibitor, calcium-channel blocker, diuretic, glucosamine, diuretic, nitrate, ACE inhibitor, calcium-channel blocker, or a beta-blocker), supplements, and medical foods tailored for hypertensive subjects (i.e. sodium restriction, low-sodium diet, or salt sensitivity products). Many treatments for hypertension have been proven by randomized controlled trials to be safe and confer significant benefit. Many of these treatments are relatively safe and cost-effective with no adverse effect on patient morbidity or mortality.

Anonymous Patient Answer

What causes hypertension?

The causes of hypertension are multiple and include excessive renin activity, vasoconstriction of the sympathetic nervous system, and aldosterone secretion. Most people with hypertension also have hypertension and/or obesity with or without comorbidities and in many cases, the cause is unknown.

Anonymous Patient Answer

Can hypertension be cured?

We can not state that a cure has been confirmed in the light of the data evaluated here. On the other hand, we suppose that it looks likely that the possibility of curing hypertension is possible. More prospective investigations should be performed with a better selection criterion of prospective patients with the help of more elaborate studies.

Anonymous Patient Answer

What are the signs of hypertension?

Hypertension is associated with several common signs, such as nasal congestion, dizziness and fatigue. These symptoms contribute to patient distress and may adversely affect quality of life.

Anonymous Patient Answer

How does quartet ldqt work?

Quartet LDqt may relieve pain, but for many people it hasn’t been shown to prevent or treat other symptoms of high blood pressure. There is a lack of information on side effects. There have been no long term studies done on quartet LDqt in the long term. There are currently few studies on quartet LDqt which only tested for short term pain. There are very few studies which explain how it was developed, and it is only on the market for 6 years, so the evidence base for it is very weak.

Anonymous Patient Answer

What is the primary cause of hypertension?

Hypertension is most common among people with diabetes mellitus, with obesity, and those with other medical conditions not usually seen with hypertension. I am not aware of any compelling evidence that establishes the superiority of one treatment over another for primary hypertension.

Anonymous Patient Answer

What are the common side effects of quartet ldqt?

The frequent adverse events of Quartet LDQ are gastrointestinal such as nausea, vomiting, itch, diarrhea and constipation, and some general symptoms such as insomnia, restlessness and dizziness. The most common side effect is neutropenia. It is advised that patients, particularly those who are taking antimalarial drugs, who complain of fever and myalgia be investigated for evidence of malignancy. It is reported that in some cases a prolonged QT interval can be observed when patients take one of the components of Quartet (for example, atorvastatin, clopidogrel, etc.). Therefore, patients should be informed of this possible side effect.

Anonymous Patient Answer

What are the latest developments in quartet ldqt for therapeutic use?

Recent advances from the NIH/NHLBI were highlighted which involved the development of novel therapeutic targets like the SGLT (sodium glucose cotransporter)1. The new therapeutic drug discovery platforms are a potentially valuable asset to current treatment of hypertension because of their flexibility in pharmacology, tolerability, ease of synthesis and their lack of interaction with other treatment options in antihypertensive therapy like SGLT2 (sodium glucose cotransporters) inhibitors and the other therapeutics like calcium channel antagonists.

Anonymous Patient Answer

Does quartet ldqt improve quality of life for those with hypertension?

This was a pilot study which demonstrated that quartet ldqt may be of benefit, at a low cost, in the management of patients with mild to moderate hypertension. The effect size, on HRQoL, was small. On this basis, further research, in the context of a larger clinical trial, is needed to establish a final conclusion.

Anonymous Patient Answer
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