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Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg for High Blood Pressure (GMRx2_PCT Trial)

Phase 3
Recruiting
Led By Anthony Rodgers, Professor
Research Sponsored by George Medicines PTY Limited
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 days
Treatment 3 months
Follow Up 1 months
Awards & highlights

GMRx2_PCT Trial Summary

This trial will test how well a combination of three low-dose drugs works to control blood pressure, compared to a placebo.

Eligible Conditions
  • High Blood Pressure

GMRx2_PCT Trial Timeline

Screening ~ 3 days
Treatment ~ 3 months
Follow Up ~1 months
This trial's timeline: 3 days for screening, 3 months for treatment, and 1 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference in change in home SBP from baseline to Week 4
Secondary outcome measures
Difference in change in clinic seated mean DBP from baseline to Week 4
Difference in change in clinic seated mean SBP from baseline to Week 4
Difference in change in home seated mean DBP from baseline to Week 4
+6 more
Other outcome measures
Safety Outcomes

GMRx2_PCT Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Triple ¼ (GMRx2)Experimental Treatment1 Intervention
Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg
Group II: Triple ½ (GMRx2)Active Control1 Intervention
Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg
Group III: PlaceboPlacebo Group1 Intervention
Placebo

Find a Location

Logistics

Other reimbursement is provided

Other forms of reimbursement are provided for this trial.

Who is running the clinical trial?

George Medicines PTY LimitedLead Sponsor
2 Previous Clinical Trials
1,719 Total Patients Enrolled
Anthony Rodgers, ProfessorPrincipal InvestigatorThe George Institute
1 Previous Clinical Trials
1,385 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has this combination of Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg been studied before?

"In 2012, the efficacy of telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg was first explored in a clinical trial at UT Southwestern Medical Center. Since then, a total of 18694 similar studies have been completed. Right now, 40 are active with a large number of these studies taking place in Tampa, Arizona."

Answered by AI

What indications does Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg commonly treat?

"Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg is most often used to help prevent cardiovascular events. It can also be used to lower the risk of cardiovascular disease, dyslipidemias, and sodium and fluid retention."

Answered by AI

What are the risks associated with Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg?

"Telmisartan 10 mg/amlodipine 1.25 mg/indapamide 0.625 mg has received a score of 3 for safety. This is because it is a phase 3 trial, which there is some evidence of efficacy and multiple rounds of data supporting safety."

Answered by AI

Are people still able to enroll in this trial?

"The clinical trial is recruiting for 250 patients at 23 locations."

Answered by AI

What is the total amount of participants for this clinical trial?

"Yes, the most recent information on clinicaltrials.gov suggests that this particular clinical trial is looking for new patients to enroll. This trial was first posted on 6/6/2021 and was edited on 8/19/2022. A total of 250 patients are being accepted at 23 different sites."

Answered by AI

Who else is applying?

What state do they live in?
California
Other
Florida
Texas
How old are they?
18 - 65
What site did they apply to?
Precision Research Center
Valiance Clinical Research
North Hills Medical Research
Other
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+
1
2
0

Why did patients apply to this trial?

Try something new. To help reduce high blood pressure. I had recent physical, surprised to learn how high my bp is.
PatientReceived 2+ prior treatments
I would like to take control of my blood pressure without taking 2 or more medications in hope that it will help others in the future.
PatientReceived no prior treatments
I'm retired at home alone. SOmething to do and meet people make a few dollars! Meet people MOST IMPORTANT LEARN ABOUT MY HEALTH CONDITION.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

Yes what are the requirements how much does it pay location near Houston Texas 77035 and how long does it last?
PatientReceived 1 prior treatment
How urgent is it to travel to Tarzana, is there a clinic in West Tennessee or Eastern Arkansas? Also, what is the prescription for this trial?
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. North Hills Medical Research: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension
2021. "Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04518306.
~65 spots leftby Apr 2025
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