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Angiotensin II Receptor Blocker
ACE Inhibitors + Exercise for High Blood Pressure (ACES Trial)
Phase 2
Waitlist Available
Led By Thomas Buford, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
> 290 seconds needed to complete long-distance corridor walk test
Age 60 years and older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 32 weeks
Awards & highlights
ACES Trial Summary
This trial will test if different types of blood pressure medication combined with physical exercise can improve functional status and cardiovascular risk factors in older adults with hypertension.
Who is the study for?
This trial is for seniors aged 60 and above with high blood pressure who lead a sedentary lifestyle, doing less than 150 minutes of moderate exercise per week. They must be willing to follow the study procedures and allow communication with their doctor. People with severe heart conditions, recent heart attacks, significant cognitive impairment, known allergies to ACE inhibitors, kidney or liver issues are not eligible.Check my eligibility
What is being tested?
The ACES trial is testing whether different blood pressure medications (Losartan or Perindopril) combined with aerobic exercise affect seniors' physical function and cardiovascular risk factors differently compared to HCTZ medication alone. Participants will be randomly assigned to one of these treatment combinations in this controlled study.See study design
What are the potential side effects?
Possible side effects from the medications include coughing, dizziness due to low blood pressure, high potassium levels which can affect heart rhythm, kidney problems, and allergic reactions. Exercise may cause muscle soreness or increase injury risk if not done properly.
ACES Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
It takes me more than 290 seconds to complete a long walk test.
Select...
I am 60 years old or older.
Select...
I have high blood pressure, treated or untreated.
ACES Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 32 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~32 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Gait speed
Secondary outcome measures
Body composition
Circulating indices of cardiovascular risk
Six minute walk test
ACES Trial Design
3Treatment groups
Active Control
Group I: PerindoprilActive Control2 Interventions
4 mg qd titrated to 8 mg qd perindopril + aerobic exercise
Group II: LosartanActive Control2 Interventions
50 mg qd titrated to 100 mg qd losartan + aerobic exercise
Group III: HCTZActive Control2 Interventions
12.5 mg qd titrated to 25 mg qd HCTZ + aerobic exercise
Find a Location
Who is running the clinical trial?
University of Alabama at BirminghamLead Sponsor
1,588 Previous Clinical Trials
2,280,099 Total Patients Enrolled
University of Colorado, DenverOTHER
1,734 Previous Clinical Trials
2,148,670 Total Patients Enrolled
Translational Research Institute for Metabolism and Diabetes, Advent Health HospitalUNKNOWN
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- It takes me more than 290 seconds to complete a long walk test.I do not have severe heart problems like heart failure, aortic stenosis, or uncontrolled chest pain.You have been diagnosed with severe memory or thinking problems, or you scored less than 24 on a memory and thinking test.My blood pressure is over 140/90 even though I'm on three or more blood pressure medications.You don't exercise regularly, with less than 150 minutes of moderate physical activity per week.You recently had a heart attack, as shown in an ECG.I am 60 years old or older.Your blood pressure is too high (above 180 over 110).I agree to all study procedures and allow communication with my doctor.I have high blood pressure, treated or untreated.You are allergic to ACE inhibitors, but you can still participate in the study if you are assigned to a different treatment.I have chronic kidney disease.Your blood test shows high levels of creatinine, which could indicate kidney problems.Your liver enzymes are higher than they should be.Your blood potassium levels are not in the normal range.You have high levels of protein in your urine.
Research Study Groups:
This trial has the following groups:- Group 1: Perindopril
- Group 2: Losartan
- Group 3: HCTZ
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What medical conditions does Perindopril usually help alleviate?
"Perindopril is most commonly used to treat left ventricular hypertrophy. It can also be prescribed to treat multiple other conditions, such as proteinuria, high cardiovascular risk, and cerebrovascular accident."
Answered by AI
What other Perindopril-based research has been published?
"Out of the 32 Perindopril clinical trials, 2 are currently in Phase 3. Most of these studies are based out of San Francisco but there are 544 locations conducting research on this medication."
Answered by AI
Are there any open vacancies for this clinical trial?
"Yes, this information is available on clinicaltrials.gov. The posting date was May 29th, 2018 and the most recent update was on May 6th, 2022."
Answered by AI
How many individuals are a part of this research project?
"In order to complete this study, 213 patients that fall under the specific inclusion criteria are required. These individuals can participate from numerous locations such as Translational Research Institute in Orlando, Florida and University of Colorado Medical Center in Aurora, Colorado."
Answered by AI
What is the margin of safety for Perindopril?
"Perindopril's safety was given a score of 2 because, while Phase 2 trials provide some evidence of safety, there is no data currently supporting efficacy."
Answered by AI
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