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Antihypertensive drugs
Intensive Blood Pressure Treatment for High Blood Pressure (HIPAC Trial)
Phase 2
Waitlist Available
Led By David Zhu, PhD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy normotensive subjects (24-hour ambulatory BP<125/75 mmHg without use of antihypertensive medication)
Patients with hypertension defined as 24-hour SBP ≥130 mmHg, patients on BP medications are eligible
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6-months,12-months
Awards & highlights
HIPAC Trial Summary
This trial will test if lowering blood pressure alters brain pulsatility and reduces amyloid beta protein accumulation in older adults.
Who is the study for?
Adults aged 55-79 with high blood pressure, able to follow up for a year, and fluent in English can join. They must have normal cognitive function (MMSE > 26), no severe brain or heart conditions, not be pregnant, and without recent drug/alcohol abuse. Those on blood pressure meds or healthy individuals with normal blood pressure are also eligible.Check my eligibility
What is being tested?
The HIPAC Trial is testing if lowering high blood pressure in older adults using approved medications can affect brain pulsatility and reduce amyloid-beta protein accumulation—a factor linked to Alzheimer's disease—to improve memory and thinking.See study design
What are the potential side effects?
Possible side effects from antihypertensive drugs may include dizziness, headaches, fatigue, low blood pressure symptoms like fainting especially when standing up quickly (orthostatic hypotension), and potential kidney effects.
HIPAC Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My blood pressure is healthy without medication.
Select...
I have high blood pressure or am on medication for it.
HIPAC Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 6-months,12-months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6-months,12-months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Changes in intracranial pulsatility
Secondary outcome measures
Brain neural network functional connectivity via Magnetic Resonance Imaging (MRI)
Brain white matter hyperintensity (WMH) via Magnetic Resonance Imaging (MRI)
Brain white matter microstructural integrity via Magnetic Resonance Imaging (MRI)
+7 moreHIPAC Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Intensive TreatmentExperimental Treatment1 Intervention
Subjects in the intensive treatment arm will receive calcium channel blocker (CCB, amlodipine), angiotensin II receptor blocker (ARB, losartan), and other antihypertensive drugs to reduce 24-hour SBP ≤ 120 mmHg.
Group II: Standard CareActive Control1 Intervention
Subjects in the standard care arm will receive calcium channel blocker (CCB, amlodipine), angiotensin II receptor blocker (ARB, losartan), and other antihypertensive drugs to reduce 24-hour SBP ≤ 130 mmHg. Drug doses will be titrated to reach the BP target.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intensive Treatment
2010
N/A
~30
Find a Location
Who is running the clinical trial?
University of Texas Southwestern Medical CenterLead Sponsor
1,047 Previous Clinical Trials
1,053,679 Total Patients Enrolled
Michigan State UniversityOTHER
184 Previous Clinical Trials
601,287 Total Patients Enrolled
Texas Health ResourcesOTHER
14 Previous Clinical Trials
20,020 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have a carotid stent or severe narrowing of my carotid artery.You are afraid of being in small, enclosed spaces.You need to score more than 26 on a test to make sure you don't have memory or thinking problems.You have a severe mental health condition like depression.My kidney function is low, with a GFR under 40 ml/min.Your blood pressure drops significantly when you stand up.You have struggled with drug or alcohol abuse in the past 2 years.I am between 55 and 79 years old.I have been diagnosed with Alzheimer's disease or another type of dementia.I do not have recent severe heart issues or other serious health conditions.My blood pressure is healthy without medication.I have high blood pressure or am on medication for it.I have a history of B12 deficiency or hypothyroidism but have been stable on treatment for at least 3 months.I have high blood pressure and am open to any treatment group, and can visit the clinic for a year.I am between 55 and 79 years old.You have smoked cigarettes regularly in the past year.My BMI is 45 or higher.My diabetes is not under control, with high blood sugar or A1C levels.I have high blood pressure or am on medication for it.I have obstructive sleep apnea.I have had a stroke, TIA, brain injury, or severe brain blood vessel disease.I have a history of serious autoimmune diseases like lupus or rheumatoid arthritis.
Research Study Groups:
This trial has the following groups:- Group 1: Intensive Treatment
- Group 2: Standard Care
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Has Intensive Treatment obtained the necessary authorization from the FDA?
"The safety of Intensive Treatment is rated 2 out of 3 due to the preliminary findings that suggest it is safe, but there is yet to be evidence supporting its efficacy."
Answered by AI
Are there still vacancies in this clinical research project for enrollees?
"Information on clinicaltrials.gov suggests that, while this medical study was last updated in August of 2022, it is not recruiting patients at the present time. However, there are 755 other research initiatives actively looking for eligible participants."
Answered by AI
Is my participation in this trial permissible?
"This research study seeks to enrol 120 individuals aged between 55 and 79, who have been diagnosed with hypertension. It is essential that these patients fulfil the following prerequisites: must belong to any racial or ethnic group; men and women are accepted; no cognitive impairment (MMSE > 26)."
Answered by AI
Does the protocol necessitate that participants must be 40 or under to join this trial?
"The eligibility requirements of this experiment dictate that the participants should be between 55 and 79 years old. There are 57 studies for minors, whilst 667 trials recruit patients above 65."
Answered by AI
Who else is applying?
What state do they live in?
Texas
What site did they apply to?
UT Southwestern Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
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