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Antisense Oligonucleotide

IONIS-AGT-LRx for High Blood Pressure (ASTRAAS Trial)

Phase 2
Waitlist Available
Research Sponsored by Ionis Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to day 169
Awards & highlights

ASTRAAS Trial Summary

This study is evaluating whether a drug may help lower blood pressure in individuals with high blood pressure.

ASTRAAS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to day 169
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to day 169 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Seated Automated Office Systolic Blood Pressure (SBP) from Baseline to Study Day 85
Secondary outcome measures
Change from Baseline in plasma AGT to each scheduled, post-baseline visit
Change from Baseline on seated automated office DBP to each scheduled, post-Baseline visit
Change from Baseline on seated automated office SBP to each scheduled, post-Baseline visit
+4 more

ASTRAAS Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: IONIS-AGT-LRxExperimental Treatment1 Intervention
Multiple doses of IONIS-AGT-LRx will be administered subcutaneously once-weekly for 12 weeks.
Group II: PlaceboPlacebo Group1 Intervention
IONIS-AGT-LRx-matching placebo will be administered subcutaneously once-weekly for 12 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
IONIS-AGT-LRx
2021
Completed Phase 2
~240

Find a Location

Who is running the clinical trial?

Ionis Pharmaceuticals, Inc.Lead Sponsor
146 Previous Clinical Trials
15,122 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Mississippi
Arizona
How old are they?
18 - 65
What site did they apply to?
Elite Clinical Studies
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
2021. "A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04714320.
~39 spots leftby Apr 2025
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