CLINICAL TRIAL

Treatment for Hyperhidrosis

Recruiting · 18+ · All Sexes · Murray, UT

This study is evaluating whether a cloth that is worn on the amputation site can help reduce sweating.

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About the trial for Hyperhidrosis

Eligible Conditions
Hyperhidrosis · Amputations

Treatment Groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
patients who screened positive for HDDS (HDSS of 3 or greater) and also had an ASDD-m item 2 severity score of 4 or greater were more likely to have a significantly lower PFFQ score (PFFQ score of >= 4) than those who screened positive for HDDS but did not have an ASDD-m item 2 severity score of 4 or greater. show original
Limb amputation surgery is a procedure in which a limb is removed from the body show original
To have a prosthetic device is to have a fake leg or arm. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 2 primary outcomes and 1 secondary outcome in patients with Hyperhidrosis. Measurement will happen over the course of 4 weeks.

Determine if patient's disease-related life quality is changed as a result of glycopyrronium cloth use as measured by the SKINDEX-16
4 WEEKS
Skindex-16 has 16 questions that accurately and sensitively measures how much patients are bothered by their skin conditions. We will determine the change in SKINDEX-16 scores between treatment and placebo periods. Skindex includes 16 questions that are rated on a scale from 0-6 (0 meaning never bothered by skin condition and 6 meaning always bothered by skin condition).
4 WEEKS
Determine if daily use of glycopyrronium cloths applied to the amputation site decreases hyperhidrosis severity and improved fit and function of the prosthetic as measured by the ASDD-m.
4 WEEKS
ASDD-m is a questionnaire for axillary hyperhidrosis measuring for presence, severity, impact and bothersomeness of the patient's sweating. There is a question that a patient rates from 0-10 (0 meaning no sweating at all, and 10 meaning worst possible sweating). Then there are two questions grated on a scale of 0-4 (0 meaning not at all and 4 meaning an extreme amount). So in total of 18 points with 0 meaning not bothered by swat at all, and 18 meaning that patients are extremely bothered by sweat.
4 WEEKS
Determining the change in the average weekly step count of weeks using the study treatment to weeks not using the study treatment.
12 WEEKS
Patients will wear an activity monitor and we will compare their weekly average step count during the screening period to week 4 to the treatment period.
12 WEEKS

Who is running the study

Principal Investigator
S. Z. K.
Prof. Stephanie Z Klein, Assistant Professor, Dermatology, Principal Investigator
University of Utah

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does treatment improve quality of life for those with hyperhidrosis?

In patients with mild to moderate chronic stress, treatment improved QoL, especially when using topical creams. Future research should be done in patients with severe stress for a longer follow-up period and in patients with chronic more severe stress to evaluate the effect of treatment on QoL over a longer period.

Anonymous Patient Answer

Has treatment proven to be more effective than a placebo?

Results suggest that a 6-week course of the medication tetrabenazine is more effective than placebo when treating generalized hyperhidrosis. This treatment may be useful when treating patients with mild to moderate-severe generalized hyperhidrosis associated with severe symptoms or chronic hyperhidrosis.

Anonymous Patient Answer

What are common treatments for hyperhidrosis?

The treatment of hyperhidrosis depends on the individual's characteristics. Treatment may include medications or non-pharmacological treatments. Surgical options may increase the volume of sweating via cutaneous sweating bypass.

Anonymous Patient Answer

Can hyperhidrosis be cured?

It seems that this condition does not require a single medical treatment as it is the result of a disturbance of the sympathetic nervous system.

Anonymous Patient Answer

How many people get hyperhidrosis a year in the United States?

About 2 million Americans were evaluated for hyperhidrosis annually. Women are affected more frequently than men. The rate of hyperhidrosis increases with age. The condition does not have the same impact as it does in Europe and is associated with more social impacts.

Anonymous Patient Answer

What are the signs of hyperhidrosis?

There are many signs that signify the presence of hyperhidrosis. These signs include the inability to dry clothing off after showering, frequent body washing, and sweating with and without heat. These symptoms, along with the unpleasantness of sweating, can cause great stress.

Anonymous Patient Answer

What is hyperhidrosis?

In most cases, hyperhidrosis has become a natural part of childhood. Children must be informed about the diagnosis, and encouraged to discuss a course of treatment with a pediatric dermatologist, who will perform a comprehensive evaluation of the condition, review medication contraindications, and provide patient education before the treatment is offered.

Anonymous Patient Answer

What causes hyperhidrosis?

Hyperhidrosis has a multitude of possible causes and treatments have been explored over the years. It can be classified into four primary forms: idiopathic, secondary, congenital, and neurological. In most cases, a combination of the primary forms is the cause. This article will focus on the most common secondary causes of hyperhidrosis, including medications and alcohol dependence, as well as treatments.

Anonymous Patient Answer

Is treatment safe for people?

Overall, this study showed no significant side effects to treatment with ETS and is effective and safe for a patient population with moderate to severe hyperhidrosis.

Anonymous Patient Answer

How serious can hyperhidrosis be?

It is important to know that patients are advised not to sweat on the face. This includes the chest, abdomen, genitals and even the eyelids. Hyperhidrosis may also occur in patients taking antidepressants or with a history of depression, and is more likely if they are of a younger ages. I have noticed that patients with hyperhidrosis of the upper trunk are more likely to have [lower back pain](https://www.withpower.com/clinical-trials/lower-back-pain) and, more importantly, neck pain, as compared to those patients with hyperhidrosis of the lower torso.

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

According to our study, the treatment most commonly used in combination with any other treatments is photorefractive keratectomy (PRK). Treatment was most frequently used with surgical therapies in conjunction with other forms of therapies. Patients with hyperhidrosis who are also concerned about the aesthetics of their skin may use treatments with cosmetic aims, such as PRK, to boost the appeal of the skin.

Anonymous Patient Answer

Have there been any new discoveries for treating hyperhidrosis?

Most medicines are effective for primary hyperhidrosis treatment. We can recommend anticholinergics for treating primary hyperhidrosis, and a low dosage anti-allergy, which can be used as a substitute for anticholinergic treatment to reduce the excessive sweating in patients with severe secondary hyperhidrosis.

Anonymous Patient Answer
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