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Statins

Open Label, Single Arm Technology-Assisted Cholesterol Trial for High Cholesterol (TACTiC Trial)

Phase 3
Waitlist Available
Led By William C. Miller, M.D.
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, approximately 6 months
Awards & highlights

TACTiC Trial Summary

This trial is testing whether people can safely and effectively buy and use Crestor over-the-counter for six months.

Eligible Conditions
  • High Cholesterol

TACTiC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, approximately 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, approximately 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent change from baseline in verified LDL-C to Visit 2
Percentage of participants with an Overall Correct (correct + mitigated) Final Use Outcome at the final use assessment
Percentage of participants with an Overall Correct (correct + mitigated) Initial TASS Outcome at the initial self-selection
Secondary outcome measures
Cholesterol retest within 6 months of starting medication (that was verified at Visit 2, not including study mandated tests) by at least 60% of participants who are eligible for continuous treatment
Percentage of participants who correctly self-identify as having a "Do Not Use" warning at the final use assessment
Percentage of participants who correctly self-identify as having a "Stop Use" warning and stop medication
+4 more
Other outcome measures
Difference in % change from baseline in LDL-C between participants who had a retest during the study with a verified source and those who did not retest but had a study mandated test completed based on participants eligible for continuous treatment at V2
For participants who correctly self-identify a "Stop Use" warning and stopped the medication, the date from when participant self-identifies a "Stop Use" warning to the date the medication was stopped
For participants who correctly self-identify a "Stop Use" warning and talked to a doctor, the date from when a participant self-identifies a "Stop Use" warning to the date their doctor was contacted
+7 more

TACTiC Trial Design

1Treatment groups
Experimental Treatment
Group I: Open Label, Single Arm Technology-Assisted Cholesterol TrialExperimental Treatment1 Intervention
Open Label Single Arm study in All-comers population who self-report having concern about high cholesterol or heart health
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
5 mg rosuvastatin calcium with a Web App (combination product)
2021
Completed Phase 3
~1190

Find a Location

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,272 Previous Clinical Trials
288,611,486 Total Patients Enrolled
8 Trials studying High Cholesterol
9,833 Patients Enrolled for High Cholesterol
Concentrics Research LLCUNKNOWN
Concentrics Research - STATKING JVUNKNOWN

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What primary goals does this experiment seek to realize?

"The aim of this clinical trial, which will be gauged over a period of 6 months, is to study the percentage of participants that have a positive final use outcome. Additionally, the secondary outcomes of this trial include the percentage of participants who correctly identify a "Stop Use" warning and comply with the medication regimen, the percentage of participants that are considered compliant with continuous dosing, and finally, the percentage of participants who correctly identify a "Do Not Use" warning."

Answered by AI

Can you share any other research that has been conducted on this treatment method?

"45 different clinical trials are currently underway to research this treatment. Of those, 13 are in Phase 3. The 331 locations conducting these trials are primarily based in Miami, Florida."

Answered by AI

Who can sign up to be a part of this research?

"This trial is seeking 1189 individuals aged 20-75 who have cholesterol. Patients must also meet the following criteria: 1. Must have signed the Informed Consent form, Males, 20-75 years of age, Females, 20-75 years of age (Inclusion criteria for females will be revised to only enrolling women aged 50-75 once 50 women under 50 have been enrolled in the study), Responding to advertising about high cholesterol or heart health concerns, Must be able to read, speak, and understand English, Additional Criteria for Inclusion for Actual Use (at Virtual Visit 1)."

Answered by AI

How many people are being chosen to participate in this experiment?

"This study isn't recruiting patients at the moment, however that could change in the future. The trial was first posted on July 8th, 2021 and was last updated on September 29th, 2022. If you're interested in similar studies, there are 72 clinical trials actively recruiting patients with cholesterol and 45 trials for this treatment actively recruiting participants."

Answered by AI

Are seniors eligible for this research project?

"This trial's age range begins at 20 years old and concludes at 75 years old."

Answered by AI

Has this therapy been cleared by the FDA?

"This is a Phase 3 trial, which means that while there is some data supporting efficacy, multiple rounds of data supporting safety exist--so our team at Power rates the safety of this treatment as a 3."

Answered by AI

What are the primary diseases that this treatment is designed to target?

"Medications in this class are typically used to treat hypertriglyceridemia. They may also be effective for preventing cardiovascular disease, cardiovascular events, and complications from cardiovascular surgeries."

Answered by AI

Are there any available positions for trial participants?

"As of now, this study is not recruiting patients for participation. The trial was originally posted on July 8th, 2021 and was most recently updated on September 29th, 2022. If you are looking for other trials, there are 72 cholesterol studies and 45 trials for this specific treatment that are actively recruiting patients."

Answered by AI
Recent research and studies
~317 spots leftby Apr 2025