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Dietary Supplement

Rosuvastatin for High Cholesterol (SPORT Trial)

Phase 2
Waitlist Available
Led By Luke Laffin, M.D.
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the percent change in high sensitivity c reactive protein (hscrp) for rosuvastatin 5 mg and dietary supplements compared with placebo after 4 weeks.
Awards & highlights

SPORT Trial Summary

This study is evaluating whether a statin medication or several dietary supplements may help lower LDL cholesterol.

SPORT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent Change in LDL-C From Baseline for Rosuvastatin 5mg Daily Compared With Placebo and Each Dietary Supplement.
Secondary outcome measures
Percent Change in HDL-C, Total Cholesterol, and Triglycerides for Rosuvastatin vs Dietary Supplements.
Percent Change in hsCRP for Rosuvastatin vs Dietary Supplements.
The Percent Change in HDL-C, Total Cholesterol, and Triglycerides for Placebo vs the Dietary Supplements.

SPORT Trial Design

8Treatment groups
Active Control
Placebo Group
Group I: RosuvastatinActive Control1 Intervention
5 mg once per day
Group II: Fish OilActive Control1 Intervention
Nature Made 2 soft gels per day
Group III: CinnamonActive Control1 Intervention
1200mg, 2 capsules per day
Group IV: GarliqueActive Control1 Intervention
Manufactured by Focus Consumer Health Marketgate,1 tablet per day
Group V: TurmericActive Control1 Intervention
Bio Schwartz Turmeric Curcumin 1500 mg, 3 capsules per day
Group VI: Plant SterolActive Control1 Intervention
Nature Made CholestOff Plus, 2 soft gels twice a day
Group VII: Red Yeast RiceActive Control1 Intervention
Arazo Nutrition 1200 mg, 2 capsules per day
Group VIII: PlaceboPlacebo Group1 Intervention
comparable to rosuvastatin 5 mg once per day

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,025 Previous Clinical Trials
1,365,673 Total Patients Enrolled
2 Trials studying High Cholesterol
1,249 Patients Enrolled for High Cholesterol
AstraZenecaIndustry Sponsor
4,253 Previous Clinical Trials
288,537,980 Total Patients Enrolled
9 Trials studying High Cholesterol
11,022 Patients Enrolled for High Cholesterol
Luke Laffin, M.D.Principal InvestigatorThe Cleveland Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Supplements, Placebo, or Rosuvastatin Study
2021. "Supplements, Placebo, or Rosuvastatin Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04846231.
~52 spots leftby Apr 2025
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