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Enzyme Replacement Therapy

AEB1102 for Arginase I Deficiency (AEB1102 Trial)

Phase 2
Waitlist Available
Research Sponsored by Aeglea Biotherapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 4 years
Awards & highlights

AEB1102 Trial Summary

This trial is testing a new drug to see if it is safe and effective.

Eligible Conditions
  • Arginase I Deficiency
  • Hyperargininemia

AEB1102 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 4 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 4 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of treatment-related adverse events
Secondary outcome measures
Cmax Cmin

AEB1102 Trial Design

1Treatment groups
Experimental Treatment
Group I: AEB1102Experimental Treatment1 Intervention
Each patient may receive AEB1102 administered IV for up to approximately 4 years.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AEB1102
2017
Completed Phase 2
~30

Find a Location

Who is running the clinical trial?

Aeglea BiotherapeuticsLead Sponsor
7 Previous Clinical Trials
259 Total Patients Enrolled
3 Trials studying Arginase I Deficiency
51 Patients Enrolled for Arginase I Deficiency
Josie GaytonStudy DirectorAeglea Biotherapeutics, Inc.
4 Previous Clinical Trials
119 Total Patients Enrolled
3 Trials studying Arginase I Deficiency
51 Patients Enrolled for Arginase I Deficiency
Cortney CaudillStudy DirectorAeglea Biotherapeutics, Inc.
3 Previous Clinical Trials
48 Total Patients Enrolled
2 Trials studying Arginase I Deficiency
35 Patients Enrolled for Arginase I Deficiency

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has AEB1102 been given the green light by the FDA?

"AEB1102 has been assigned a preliminary safety score of 2, as there is evidence that it can be consumed without risk but nothing yet to suggest its efficacy."

Answered by AI

How widespread is the implementation of this trial?

"At this time, participants can join the trial at 5 different sites around North America, such as New york City, Dallas and Toronto. To reduce travel costs to a minimum, please select a clinical centre near your residence."

Answered by AI

What prior examinations have been conducted involving AEB1102?

"Presently, there are two AEB1102 studies in the process of being conducted - one is already at Phase 3. Although much of the research activity for this medication occurs near Porto, California, trial sites can be found across 40 locations nationwide."

Answered by AI

How many participants are enrolled in this clinical research endeavor?

"At the current time, this investigation is not in need of any more enrollees. The protocol was initially uploaded on December 7th 2017 and had its most recent update on July 22nd 2022. For those exploring other medical research projects, there are two separate studies searching for patients suffering from hyperargininemia and 2 trials involving AEB1102 actively recruiting test subjects."

Answered by AI

Does this medical experiment represent a pioneering effort?

"Presently, there are two active trials for AEB1102 spanning 8 different nations and 21 cities. Aeglea Biotherapeutics commenced the initial trial in 2017 with 14 patients; it successfully achieved Phase 2 drug approval status before 4 additional studies were conducted since then."

Answered by AI

Is this research actively seeking participants?

"This clinical trial is not currently open for new enrolments. It was initially posted on December 7th 2017, and its most recent update took place on July 22nd 2022. To those exploring other studies, there are presently two hyperargininemia trials actively recruiting participants, as well as two AEB1102 research projects in search of patients."

Answered by AI
~2 spots leftby Apr 2025