This trial is evaluating whether ABC/DTG/3TC immediate release tablets will improve 1 primary outcome and 3 secondary outcomes in patients with HIV Infections. Measurement will happen over the course of Up to 2 years.
This trial requires 300 total participants across 2 different treatment groups
This trial involves 2 different treatments. ABC/DTG/3TC Immediate Release Tablets is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
"About 1 million new HIV infections are estimated to occur each year in the US, representing about 20% of those living with HIV. The number of new infections is likely to continue increasing; if so, this may threaten to undermine the US effort to control HIV." - Anonymous Online Contributor
"The route of HIV transmission depends partly on the sexual behavior of those entering a high risk setting, with higher rates of transmission occurring with unprotected anal sex. The HIV epidemic is due to the spread of this virus through heterosexual transmission, with men involved in the sexual behaviors associated with HIV transmission. However, there is increasing evidence of an epidemic of AIDS, especially in the United States, and it will be necessary to devise a new approach to preventing HIV infection. The risk of transmission decreases when condom use is practiced regularly. This is especially true for men who have sex with men. The sexual practices of men who have sex with men are a major cause for the epidemic in Africa. Male homosexual behavior is associated with an increased risk for contracting HIV." - Anonymous Online Contributor
"Even with advanced and prolonged HIV infection, antiviral combination HIV therapy is able to eradicate HIV infection, as determined by two- to threefold declines of the HIV RNA. Although this cure is always symptomatic, it is generally clinically effective." - Anonymous Online Contributor
"There is no single infection/disease that causes AIDS. Many conditions affect people with HIV, such as malnutrition, opportunistic infections or chronic illnesses, and the disease itself is also known by other infectious diseases transmitted by HIV. HIV and AIDS are caused by a virus that is spread by sexual contact, blood, and breastfeeding. HIV is transmitted when a person has genital fluid or mucous membranes of another person who is HIV-positive. The average person acquires HIV orally by touching a surface (such as a pillowcase or glass), or by sharing an object (for example, a needle) that is contaminated with mucosal fluid." - Anonymous Online Contributor
"Antiretroviral drugs are the primary treatment for most HIV infections. Many HIV patients also get antimalarial drugs and antifungals. Antihistamines and anxiolytics are used for migraines and depression respectively. Hormonal therapy is used to treat prostate cancer and hirsutism. Antihypertensives are administered to treat high blood pressure. Anti-obesity drugs are used to treat obesity. Antidiabetic medication is used to treat diabetes mellitus, fatty liver disease and elevated serum cholesterol. Prohormones may be used to treat estrogen deficiency in elderly women with decreased bone mineral density." - Anonymous Online Contributor
"HIV infections have been identified as a major non-communicable disease in Uganda. HIV positive individuals have high rates of respiratory and digestive infections. Other features of HIV infections include increased risk of lymphoma, Kaposi sarcoma, and other cancers. HIV-1 infection is the most common form of HIV in Uganda but a variety of viral species may also contribute. The signs and symptoms of HIV infections are due to the viral pathogens themselves and not in direct proportion to HIV virus load or immune status. The main clinical signs of HIV infections are swelling in the genital and rectal (esophagus) mucosal tissues and of the liver and adrenal glands. Signs of opportunistic infections may include unexplained fevers and weight loss." - Anonymous Online Contributor
"The abc/ddtg immediate release tablets may be a good choice in developing countries where healthcare is expensive and where some health workers have to take long walks to get medications. For industrialized countries, they may also be a reasonable option. However, the current abc/ddtg immediate release tablets do not have the durability and quality of the brand name medication. The manufacturer can make additional improvements to the pills. One might take the pills exactly the same way every day, while others might make adjustments to the dosing frequency that will improve the cost-effectiveness." - Anonymous Online Contributor
"Only two new medications have been approved for treating the hiv virus, AZT (zidovudine) and lamivudine. Both of these medications are associated with significant side effects and are typically used only when other therapies are insufficient." - Anonymous Online Contributor
"There are many types of antiretroviral therapies, and there are multiple ways of packaging abc/dtg/3tc immediate release tablets. Current FDA-approved antiretroviral medicines are not interchangeable, but other ways of packaging abc/dtg/3tc immediate release tablets might be available." - Anonymous Online Contributor
"Overall, it appears that abc/dtg/3tc has only a small effect on quality of life scores, especially among those without other treatment challenges. These data are reassuring given concerns regarding abc/dtg/3tc's potential to increase HIV transmission in resource-poor countries that already have high rates of HIV transmission." - Anonymous Online Contributor
"Recent findings shows a variety of abc/dtg/3tc treatment regimens with various combinations of other antiretroviral drugs. The authors hope that this information will aid clinicians in prescribing the most appropriate abc/dtg/3tc tablet combination for their individual patients." - Anonymous Online Contributor
"Although more participants in the abc/dtg immediate release tablet group reported feeling better after dosing compared with placebo, the two groups' mean scores did not differ after treatment. Thus, it is unclear whether abc/dtg immediate release tablets were more effective overall than placebo for HIV-related symptoms or not at all." - Anonymous Online Contributor