Maraviroc for HIV Infections
This study is evaluating whether a drug called maraviroc can be used to treat HIV in children and adolescents.
See full descriptionAbout the trial for HIV Infections
Treatment Groups
This trial involves 2 different treatments. Maraviroc is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
About The Treatment
Side Effect Profile for Maraviroc
Eligibility
This trial is for patients born any sex aged 65 and younger. There is one eligibility criterion to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Maraviroc will improve 5 primary outcomes and 14 secondary outcomes in patients with HIV Infections. Measurement will happen over the course of Screening to Week 48.
Patient Q & A Section
What are the signs of hiv infections?
In men with syphilis, a non-painful, diffuse, movable painless swelling of the penis is commonly described. In asymptomatic HIV-infected men, urethritis can often be mistaken for reactive arthritis, but urethral findings can include a chancre-like appearance. The detection of Papanicolaou smears in an uncircumcised prepuce, specifically, is not a definitive indication that the patient has an HIV infection.
Can hiv infections be cured?
As HIV treatment is becoming more effective, it is increasingly important to assess curability. Using hiv as curability has its limitations, although curable rates have risen from 12% in 1996 to 32% today. The cure rate depends on many factors, including viral mutation in individuals, selection of initial treatment, adherence, duration of treatment, and, in some cases, the presence of a co-infectious viral infection. The chances of cure are especially low if you have active HIV. It is difficult to predict when an HIV infection will progress into AIDS, when it will become incurable, or when treatment will lead to long-term remission.
What is hiv infections?
HIV is an infection which can result in a HIV related illness or disability, and has major economical and social implications. The most common form of HIV in Europe and the USA is HIV-1, transmitted from a person to a person through close contact. HIV-2 is endemic in Western Africa. Transmission of HIV is mostly through sexual activity, through infected needles or blood transfusions. HIV infections are not curable, can be controlled by medication, and a cure has not yet been discovered. AIDS is a chronic and often life threatening illness related to HIV/AIDS that does not discriminate between sexes and can even cause infertility, which is why people often do not find out they are infected.
What are common treatments for hiv infections?
People with HIV are often prescribed several medications to treat a variety of unrelated conditions. Few (20%) of the medication used were related to the HIV infection. The most common treatment for HIV positivity was HAART, while HAART was often used off-label as a first-line regimen for treatment in combination with other antiretroviral agents.
How many people get hiv infections a year in the United States?
HIV infections in the United States have increased dramatically. The CDC needs to increase its surveillance of HIV infections in order to better understand the current trends of HIV infections, its consequences, and its potential treatment.
What causes hiv infections?
HIV can be contracted by sexual intercourse (up to 25%), through exposure to infected blood (up to 10% per exposure), through contamination by body fluid (up to 5% per exposure) or through blood transfusions (up to 1% per exposure). While HIV is not spread by coughing, it spread through contact with skin ulcers. Sexual practices such as oral sex (up to 50% of cases) and frotting (up to 5%) are associated with HIV. While condoms do not eradicate HIV it can prevent and reduce the transmission of the virus through sexual intercourse.
Does hiv infections run in families?
The findings demonstrated that risk for HIV infection was associated with low socioeconomic status, early age of onset of sexual activity, and number of previous sexual partners. The association between parental HIV-positive status and increased risk of offspring HIV-positive status were also found. In view of its relatively low prevalence, it seems unlikely that HIV is a true "family disease.
How does maraviroc work?
Maraviroc's effects on HIV-1 infection, and its potential use in prevention and treatment, emphasize the importance of HIV-1 dynamics and how they are regulated by drug manipulation of reverse transcription and viral replication. These studies show the importance of drug selection by cell type and drug concentration, as well as the complexity of HIV-1 infection.
Does maraviroc improve quality of life for those with hiv infections?
Most patients with HIV/HCV coinfections had good global and physical quality of life, regardless of treatment with maraviroc. Maraviroc was well tolerated and improved patient quality of life.
Is maraviroc safe for people?
Most people do not need to be treated for 3 weeks prior to starting maraviroc and one week during treatment. Those taking zidovudine for HIV treatment or receiving zidovudine or zalcitabine for other diagnoses do not require any drug interaction warnings.
How serious can hiv infections be?
The presence of HAARTs does not seem to have a substantial impact on the patient's immune status and the likelihood of developing opportunistic infections. To confirm these data, the sample size of this study was too small to be considered reliable.
What does maraviroc usually treat?
Maraviroc can be effective and well tolerated in patients with all known manifestations of infection with HCV, including those in the presence of resistance-associated mutations in the viral HCV polymerase. It is effective and well tolerated in a small number of patients with genotype-1 and genotype-4 infection.