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Monoclonal Antibodies

LY3041658 for Hidradenitis Suppurativa

Phase 2
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 16
Awards & highlights

Study Summary

This trial will test the effectiveness of the drug LY3041658 in people with moderate-to-severe hidradenitis suppurativa.

Eligible Conditions
  • Hidradenitis Suppurativa

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 16
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 16 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of Participants Achieving Hidradenitis Suppurativa Clinical Response (HiSCR) at Week 16
Secondary outcome measures
Mean Change From Baseline to Week 16 in Skin Pain on the HS Numeric Rating Scale (NRS)
Mean Change From Baseline to Week 16 in Total Number of Abscesses and Inflammatory Nodules (AN) Count

Side effects data

From 2022 Phase 2 trial • 72 Patients • NCT04493502
10%
Balanoposthitis
7%
Constipation
7%
Arthralgia
7%
Nausea
7%
Fatigue
4%
Covid-19
100%
80%
60%
40%
20%
0%
Study treatment Arm
600 mg LY3041658 _Double-Blind Treatment Period
Placebo_Double-Blind Treatment Period
600 mg LY3041658_Open-Label Extension
Follow-Up Period

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3041658Experimental Treatment1 Intervention
Participants received 600 mg LY3041658 administered intravenously (IV) once every 2 weeks (Q2W).
Group II: PlaceboPlacebo Group2 Interventions
Placebo administered IV. Participants will switch to 600 mg LY3041658 administered IV after week 16.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3041658
2020
Completed Phase 2
~150

Find a Location

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,618 Previous Clinical Trials
3,201,488 Total Patients Enrolled
1 Trials studying Hidradenitis Suppurativa
350 Patients Enrolled for Hidradenitis Suppurativa
Study DirectorEli Lilly and Company
1,347 Previous Clinical Trials
405,682 Total Patients Enrolled
1 Trials studying Hidradenitis Suppurativa
350 Patients Enrolled for Hidradenitis Suppurativa

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
A Study of LY3041658 in Adults With Hidradenitis Suppurativa
2020. "A Study of LY3041658 in Adults With Hidradenitis Suppurativa". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04493502.
~15 spots leftby Apr 2025
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