Letrozole for Hepatopulmonary Syndrome

Phase-Based Progress Estimates
University of California San Francisco, San Francisco, CAHepatopulmonary SyndromeLetrozole - Drug
18 - 99
All Sexes
What conditions do you have?

Study Summary

This trial is testing if letrozole is safe and helpful for people with Hepatopulmonary Syndrome.

Eligible Conditions
  • Hepatopulmonary Syndrome

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 3 and 6 months

3 and 6 months
Oxygen Saturation
6 months
Alveolar-Arterial Oxygen
Hormone Levels
Side effects

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Side Effects for

3%Hair loss
3%Neuro event
This histogram enumerates side effects from a completed 2018 Phase 4 trial (NCT02137538) in the Anastrozole ARM group. Side effects include: Fracture with 10%, Acne with 8%, Scoliosis with 5%, Hair loss with 3%, Sacroiliitis with 3%.

Trial Design

2 Treatment Groups

Letrozole Group
1 of 2
Placebo Group
1 of 2

Experimental Treatment

Non-Treatment Group

20 Total Participants · 2 Treatment Groups

Primary Treatment: Letrozole · Has Placebo Group · Phase 2

Letrozole Group
Experimental Group · 1 Intervention: Letrozole · Intervention Types: Drug
Placebo Group
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 3 and 6 months

Who is running the clinical trial?

Mayo ClinicLead Sponsor
2,949 Previous Clinical Trials
3,447,620 Total Patients Enrolled
1 Trials studying Hepatopulmonary Syndrome
10 Patients Enrolled for Hepatopulmonary Syndrome
University of California, San FranciscoOTHER
2,312 Previous Clinical Trials
11,758,306 Total Patients Enrolled
Hilary M DuBrock, MDPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
200 Total Patients Enrolled

Eligibility Criteria

Age 18 - 99 · All Participants · 1 Total Inclusion Criteria

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Frequently Asked Questions

To whom is this research opportunity applicable?

"This clinical experiment seeks to recruit 20 individuals with hepatopulmonary syndrome. Age criteria are between 18 and 99; however, other qualifications must also be met by participants. These include the presence of liver disease or portal hypertension, a contrast-enhanced echocardiogram showing intrapulmonary shunting, an A-a gradient ≥15mmHg (or ≥20mmHg if above 64 years old) and PaO2<80mmHg on arterial blood gas testing, Child-Pugh class A or B liver disease, MELD score < 20 for females who have experienced 12 months of natural amen" - Anonymous Online Contributor

Unverified Answer

Is this trial accepting new applicants at the present time?

"Affirmative. Clinicaltrials.gov indicates that this trial has been open since January 25th 2021 and is actively searching for 20 volunteers across 2 sites. The most recent update was made on March 23rd 2022." - Anonymous Online Contributor

Unverified Answer

Is there an age limitation to participating in this experiment?

"This medical trail is recruiting adults aged 18 to 99." - Anonymous Online Contributor

Unverified Answer

Has Letrozole been sanctioned by the FDA?

"Our safety assessment of letrozole was a 2, as it is only in Phase 2 trials and therefore lacks verifiable evidence for effectiveness." - Anonymous Online Contributor

Unverified Answer

How many participants are currently enrolled in this research program?

"Affirmative. Clinicaltrials.gov data reveals that this medical trial is still actively seeking patients, having initially been posted on January 25th 2021 and last updated on March 23rd 2022. The study requires 20 individuals to be recruited from 2 separate sites." - Anonymous Online Contributor

Unverified Answer

What evidence do we have that Letrozole may be beneficial for medical uses?

"Letrozole has been an area of research since 1995, with 18503 trials completed and 154 presently active. A substantial proportion of these investigations are being conducted in San Francisco, California." - Anonymous Online Contributor

Unverified Answer

What maladies does Letrozole typically address?

"Letrozole can be utilized to manage breast cancer, anovulatory cycle issues, and tamoxifen related treatments." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.