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Resveratrol for Congestive Heart Failure (REV-HF Trial)

Phase 2
Waitlist Available
Research Sponsored by University of Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 weeks
Awards & highlights

REV-HF Trial Summary

This trial is testing whether resveratrol, a compound found in red wine, can improve metabolic and muscle function. Patients will be given resveratrol or a placebo for 8 weeks to see if there is a difference.

Eligible Conditions
  • Congestive Heart Failure

REV-HF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Isolated Skeletal Muscle Blood Flow
Change in Oxygen extraction and consumption
Secondary outcome measures
Vascular Function by CMR

Side effects data

From 2013 Phase 2 trial • 24 Patients • NCT02114892
25%
Headache
8%
Abdominal pain
8%
Sickness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Resveratrol
Placebo

REV-HF Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ResveratrolExperimental Treatment2 Interventions
1) Resveratrol- (Transmax) trans- resveratrol (Biotivia Longevity Bioceuticals, LLC, New York, USA) in cellulose capsules. One capsule will be taken orally 2 times per day (BID) for 8 weeks.
Group II: PlaceboPlacebo Group2 Interventions
2) Placebo- 500mg (Biotivia Longevity Bioceuticals, LLC, New York, USA) in cellulose capsules. One capsule will be taken orally 2 times per day (BID) for 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Resveratrol
2014
Completed Phase 3
~730
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor
886 Previous Clinical Trials
384,765 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure
2017. "Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03525379.
~2 spots leftby Apr 2025
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