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Resveratrol for Congestive Heart Failure (REV-HF Trial)

Phase 2
Waitlist Available
Research Sponsored by University of Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 weeks
Awards & highlights

Summary

This trial tests resveratrol, a natural compound, on patients with metabolic and muscle function issues. It aims to see if resveratrol can improve blood flow and oxygen use in muscles, helping them work better and recover faster. Resveratrol is known for its potential to enhance exercise performance.

Eligible Conditions
  • Congestive Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Isolated Skeletal Muscle Blood Flow
Change in Oxygen extraction and consumption
Secondary outcome measures
Vascular Function by CMR

Side effects data

From 2013 Phase 2 trial • 24 Patients • NCT02114892
25%
Headache
8%
Abdominal pain
8%
Sickness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Resveratrol
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ResveratrolExperimental Treatment2 Interventions
1) Resveratrol- (Transmax) trans- resveratrol (Biotivia Longevity Bioceuticals, LLC, New York, USA) in cellulose capsules. One capsule will be taken orally 2 times per day (BID) for 8 weeks.
Group II: PlaceboPlacebo Group2 Interventions
2) Placebo- 500mg (Biotivia Longevity Bioceuticals, LLC, New York, USA) in cellulose capsules. One capsule will be taken orally 2 times per day (BID) for 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670
Resveratrol
2014
Completed Phase 3
~730

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor
901 Previous Clinical Trials
387,537 Total Patients Enrolled
~2 spots leftby Sep 2025
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