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Stem Cell Therapy

RECIEVED CELLS for Heart Failure (RegressHFpEF Trial)

Phase 2
Waitlist Available
Led By Michael Zile, MD
Research Sponsored by Cedars-Sinai Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up three years
Awards & highlights

RegressHFpEF Trial Summary

This trial will test whether treatment of HFPEF patients with intracoronary allogeneic CDCs (cellular therapy) is safe and affects clinical functional status, exercise tolerance, exercise hemodynamics, myocardial interstitial fibrosis, macroscopic fibrosis, and diastolic function.

Eligible Conditions
  • Heart Failure
  • Congestive Heart Failure

RegressHFpEF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~three years
This trial's timeline: 3 weeks for screening, Varies for treatment, and three years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
the safety profile of CAP 1002; any subjects experiencing any safety related events during or post intracoronary delivery and during the follow up period.

RegressHFpEF Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: RECIEVED CELLSActive Control1 Intervention
this arm will receive the CDCs /CAP 1002 solution
Group II: CONTROL ARMPlacebo Group1 Intervention
this arm will receive a solution during randomization but will not receive the CDCs

Find a Location

Who is running the clinical trial?

Cedars-Sinai Medical CenterLead Sponsor
500 Previous Clinical Trials
164,823 Total Patients Enrolled
11 Trials studying Heart Failure
10,014 Patients Enrolled for Heart Failure
Medical University of South CarolinaOTHER
933 Previous Clinical Trials
7,394,596 Total Patients Enrolled
3 Trials studying Heart Failure
185 Patients Enrolled for Heart Failure
Michael Zile, MDPrincipal InvestigatorMedical University of South Carolina
4 Previous Clinical Trials
1,717 Total Patients Enrolled
4 Trials studying Heart Failure
1,717 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Eduardo Marbán, MD, PhD 2017. "Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02941705.
~5 spots leftby Apr 2025
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