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Atorvastatin for Heart Failure

Phase 2
Waitlist Available
Led By Tomas G Neilan, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will test whether atorvastatin, a cholesterol-reducing drug, can also protect the heart during chemotherapy with doxorubicin.

Eligible Conditions
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Percentage of Individuals in Each Group With a Significant Decline in the LVEF.
Secondary outcome measures
Global Longitudinal Strain
Myocardial Extracellular Volume by Cardiac MRI.
The Percentage of Participants in Each Group With New Onset Heart Failure.
+1 more

Side effects data

From 2014 Phase 3 trial • 58 Patients • NCT02084069
3%
Postoperative bleeding
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment
Control

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AtorvastatinExperimental Treatment1 Intervention
Atorvastatin will be administered at a pre determined dose The drug is taken by mouth, once a day (evening)
Group II: PlaceboPlacebo Group1 Intervention
Placebo will be administered at a pre determined dose The drug is taken by mouth, once a day (evening)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Atorvastatin
FDA approved

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalOTHER
1,609 Previous Clinical Trials
11,470,027 Total Patients Enrolled
40 Trials studying Heart Failure
98,981 Patients Enrolled for Heart Failure
Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,055 Total Patients Enrolled
48 Trials studying Heart Failure
209,325 Patients Enrolled for Heart Failure
Dana-Farber Cancer InstituteOTHER
1,079 Previous Clinical Trials
340,648 Total Patients Enrolled

Media Library

Atorvastatin Clinical Trial Eligibility Overview. Trial Name: NCT02943590 — Phase 2
Heart Failure Research Study Groups: Placebo, Atorvastatin
Heart Failure Clinical Trial 2023: Atorvastatin Highlights & Side Effects. Trial Name: NCT02943590 — Phase 2
Atorvastatin 2023 Treatment Timeline for Medical Study. Trial Name: NCT02943590 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some other potential applications for Atorvastatin?

"OHSU Hospital first began studying atorvastatin in 2005. Since then, there have been 18,671 completed trials and 73 active studies. Many of the current investigations are based in Boston, MA."

Answered by AI

To your knowledge, has a study like this been done before?

"As of right now, there are 73 ongoing clinical trials for the drug Atorvastatin in 28 countries and 162 cities. The very first study was conducted all the way back in 2005 by Merck Sharp & Dohme LLC. That particular trial had 80 participants and completed its Phase 4 drug approval stage. In the 16 years since then, a total of 18671 different clinical trials have been carried out."

Answered by AI

Are new volunteers being sought for this research project?

"According to the latest information found on clinicaltrials.gov, this study is not currently looking for new patients. The trial was posted on 1/13/2017 and updated on 11/14/2022. There are 833 other trials that are actively recruiting participants right now."

Answered by AI

Does Atorvastatin carry any long-term risks?

"While Phase 2 trials don't provide evidence of a medication's efficacy, there is some data supporting Atorvastatin's safety, so it received a score of 2."

Answered by AI

What diseases or conditions does Atorvastatin usually help with?

"While atorvastatin is mainly used as a lipid-lowering agent, it can also be given to patients postoperatively for thromboembolism prophylaxis or those with anginal pain and transient ischemic attacks."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
Tomas G. Neilan, MD 2017. "STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02943590.
~36 spots leftby Apr 2025
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