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Biguanide

Metformin hydrochloride for Heart Failure (Met-HeFT Trial)

Phase 2
Recruiting
Led By Barry Fine, MD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 month and 6 months
Awards & highlights

Met-HeFT Trial Summary

This trial is assessing whether the drug metformin can help improve heart function in patients who don't have diabetes and don't have insulin resistance.

Met-HeFT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 month and 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Minute Ventilation to Carbon Dioxide Production (VE/VCO2) Slope
Secondary outcome measures
B Type Natriuretic Peptide (BNP) level
Body Weight
Change in Dyspnea Assesment Score
+7 more
Other outcome measures
Fasting Sugar
Hemoglobin A1c
Serum Lactate

Side effects data

From 2010 Phase 4 trial • 77 Patients • NCT01589445
9%
Common Depression
7%
Abdominal discomfort
3%
Headache
3%
Dizziness
3%
Nausea
1%
Backpain
1%
Hypertension
1%
Creatinine increase
1%
Mild Diarrhoea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Metformin (002 Group)
Pioglitazone (001 Group)

Met-HeFT Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MetforminExperimental Treatment1 Intervention
Metformin for 6 months
Group II: PlaceboPlacebo Group1 Intervention
Matched placebo for 6 months
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metformin
FDA approved

Find a Location

Who is running the clinical trial?

Columbia UniversityLead Sponsor
1,433 Previous Clinical Trials
2,447,209 Total Patients Enrolled
20 Trials studying Heart Failure
6,219 Patients Enrolled for Heart Failure
Barry Fine, MDPrincipal Investigator - Columbia University
New York Presbyterian Hospital-Columbia Presbyterian Center, Trustees of Columbia University in the City of New York

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Metformin in Heart Failure Without Diabetes
Barry Fine 2019. "Metformin in Heart Failure Without Diabetes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03331861.
All > Heart Failure With Preserved Ejection Fraction
~8 spots leftby Apr 2025
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