← Back to Search

Beta Blocker

Metoprolol Tartrate for Heart Disease (ORION Trial)

Phase 3

Waitlist Available

Led By Peter Nagele, MD

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1-year from surgery

Awards & highlights

ORION Trial Summary

This trial will test if metoprolol can reduce heart complications in patients with CAD.

ORION Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1-year from surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1-year from surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-year from surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Reduction of Myocardial Injury following Post-op Beta-blocker therapy

Secondary outcome measures

Incidence of Clinically Relevant Bradycardia

Length of Post-operative Hospitalization

Monitor Post-operative Myocardial ischemia

+5 more

Other outcome measures

Adverse Events

ORION Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: MetoprololExperimental Treatment1 Intervention

Metoprolol group, 3-intravenous doses of 5mg metoprolol tartrate (over 15-minutes), and oral dose(s) of 25mg metoprolol approximately every 8 hours postoperatively for up to 3-days (or 72 hrs).

Group II: PlaceboPlacebo Group1 Intervention

Placebo comparator group, up-to-three intravenous doses of placebo comparator (over 15-minutes), and oral dose(s) of a placebo comparator approximately every 8 hours postoperatively for up to 3-days (or 72 hrs).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Metoprolol

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,837 Previous Clinical Trials

47,851,457 Total Patients Enrolled

University of ChicagoLead Sponsor

1,004 Previous Clinical Trials

819,607 Total Patients Enrolled

Washington University School of MedicineOTHER

1,935 Previous Clinical Trials

2,299,640 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the FDA's stance on Metoprolol Tartrate?

"There is some evidence of efficacy and multiple reports of safety, so Metoprolol Tartrate was given a score of 3."

Answered by AI

What precedent exists for using Metoprolol Tartrate therapeutically?

"As of today, there are 22 ongoing clinical trials studying the effects of Metoprolol Tartrate. 4 of these studies have reached Phase 3. The majority of research locations for Metoprolol Tartrate are situated in Orlando, Florida; though, altogether, 146 different centres are running active Metoprolol Tartrate trials."

Answered by AI

How is Metoprolol Tartrate most often used?

"Metoprolol Tartrate can help patients who suffer from angina pectoris, atrial fibrillation, and other conditions that cause instability in the cardiovascular system."

Answered by AI

How many enrollees does this research project have at present?

"This particular trial is no longer seeking new participants. The study was first posted on December 1st, 2016 and received its latest update on April 20th, 2018. However, if you are interested in other trials, there are currently 340 studies actively recruiting patients with heart diseases and 22 trials for Metoprolol Tartrate that have open enrolment."

Answered by AI

Are patients currently being enrolled in this trial?

"This study isn't enrolling at the moment. The listing was first posted on December 1st, 2016 and edited most recently on April 20th, 2018. However, there are presently 340 trials actively looking for participants with heart diseases and 22 trials for Metoprolol Tartrate that need patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Metoprolol to Reduce Perioperative Myocardial Injury

Peter Nagele 2016. "Metoprolol to Reduce Perioperative Myocardial Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03138603.