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Anticoagulant

Medium ACT Target for Coronary Artery Disease

Phase 2
Waitlist Available
Led By Shahyar M Gharacholou, MD, MSc
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

Study Summary

This trial is testing whether lower ACT targets during percutaneous coronary intervention (PCI) is associated with lower rates of bleeding while having similar rates of ischemic events.

Eligible Conditions
  • Coronary Artery Disease
  • Coronary Syndrome
  • Bleeding

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adverse Clinical Events
Bleeding
Secondary outcome measures
Stent Thrombosis

Trial Design

3Treatment groups
Active Control
Group I: Medium ACT TargetActive Control1 Intervention
ACT target range of 275 to 325 seconds is achieved prior to PCI if no planned glycoprotein IIb/IIIa inhibitor used
Group II: High ACT TargetActive Control1 Intervention
ACT target range of 325 to 375 seconds is achieved prior to PCI if no planned glycoprotein IIb/IIIa inhibitor used
Group III: Low ACT TargetActive Control1 Intervention
ACT target range of 225 to 275 seconds is achieved prior to PCI if no planned glycoprotein IIb/IIIa inhibitor used

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,206 Previous Clinical Trials
3,766,903 Total Patients Enrolled
28 Trials studying Coronary Artery Disease
27,110 Patients Enrolled for Coronary Artery Disease
Shahyar M Gharacholou, MD, MScPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What indications is High ACT Target commonly prescribed for?

"High ACT Target is commonly used for medical device treatment, however its efficacy in other contexts has also been observed. It can be taken to address sprains and heart conditions such as unstable angina pectoris or atrial fibrillation."

Answered by AI

Are there any spaces still available for participants in this research endeavor?

"As of today, the clinical trial is actively seeking patients. Its initial posting was on February 8th 2019 and it underwent its most recent edit on 14th February 2022 according to the data available from clinicialtrials.gov."

Answered by AI

What is the current estimated participant count for this medical research endeavor?

"Affirmative. According to clinicaltrials.gov, this experiment was initially posted back on February 8th 2019 and has been recently updated in February 14th 2022; it is currently looking for 546 patients conducted at a single site."

Answered by AI

Has the FDA approved High ACT Target for release?

"With an optimistic assessment based on the Phase 2 classification, High ACT Target can be deemed moderately safe with a score of 2. It should be noted that while safety is supported by data, efficacy has yet to be clinically confirmed."

Answered by AI

Is this the initial implementation of such a clinical trial?

"Initiated in 2006, High ACT Target has been subject to growing scrutiny and clinical trials since. The first such study was sponsored by Ash Access Technology and involved 415 participants, resulting in the drug's Phase 3 approval. Currently, 36 separate studies are underway across 197 cities spanning 21 countries."

Answered by AI

Are there previous experiments that have explored the efficacy of High ACT Target?

"At the present time, there are 12 Phase 3 experiments and 36 active trials assessing High ACT Target. Of those studies, 367 sites have been chosen to host them; particularly in Sherbrooke, Quebec."

Answered by AI
~29 spots leftby Apr 2025