This trial is evaluating whether Treatment will improve 1 primary outcome and 18 secondary outcomes in patients with Gonorrhea. Measurement will happen over the course of Baseline and up to Day 8.
This trial requires 600 total participants across 2 different treatment groups
This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
"Signs of gonorrhea involve vaginal discharge with dysuria and/or painful urination. Signs of urethral gonorrhea in men include painful urination along with a discharge from the penis that is green, white, yellow or greyish-yellow. In men who have sex with men, symptoms of chlamydia often mimic those of gonorrhea infections. Signs of other sexually transmitted infections (STIs) that can affect the genitals include painful urination, itching and swollen or red genitals are also characteristic of gonorrhea. In many cases there will be concurrent signs of STI." - Anonymous Online Contributor
"Gonorrhea is no longer a "sexually transmitted" disease and is instead treated with antibiotics. Common treatments include oral antibiotics, i.v. antibiotics in a sterile site (usually the thigh), IV antibiotics and, in the case of men who are unable to get an erection for one reason or another, penis packing. Patients may also choose to use condoms after receiving counseling and education on the disease and its transmission." - Anonymous Online Contributor
"Gonorrhea is an infection of the Ureaplasma urealyticum subgroup. Approximately half of the men infected with gonorrhea are asymptomatic. The risk factors for gonorrhea infection are younger age and having multiple partners. In men with no asymptomatic gonorrhea infection, screening is not currently recommended, although asymptomatic gonorrhea can be contracted by sexual contact. The risk of genital gonorrhea in females is greater (60%) than previously reported (30%)." - Anonymous Online Contributor
"Currently, there is no evidence of a cure for gonorrhea. However, the gonorhea bacterium can be very effectively cured by antibacterial treatment; thus, antibiotics appear to be the most important factor in management of gonorrhea. There is also evidence that antibiotics can greatly diminish the time needed to get gonorrhea in a treated individual back to normal." - Anonymous Online Contributor
"Gonorrhea is caused by the bacteria Chlamydia trachomatis. It is transmitted sexually when a person has an abnormal and painful sex arousal (e.g. if the penis is swollen or sore) or by sexual exposure to saliva, tears, or vomit. The person will not get untreated and may be passed on to others. The signs and symptoms of gonorrhea include vaginal discharge (not a vaginal odor), burning sensation during or after sex, and painful sexual intercourse. In males, the symptoms include lower abdominal or back pain, soreness in the scrotum, and swelling. Symptoms can last for weeks." - Anonymous Online Contributor
"About 13 million cases [were experienced monthly (6.7 cases/100,000 population), of whom 89% were symptomatic (12.4 cases/100,000 population)] and 1.2 million cases occurred annually in 2009. Cases [of symptomal meningitis (1.1 cases/100,000 population), in children aged 14 years or younger (0.7 cases/100,000) and in pregnant women (4.9 cases/100,000)] were uncommon. Cases [of prostatitis (0.8 cases/100,000 population) and of pneumonia (15.9 cases/100,000 population)] were uncommon." - Anonymous Online Contributor
"The proportion of women and men with an infection, gonorrhea was 5% and 15% respectively (P<0.05). Most men were discharged from the study because it complied with a request from their general practitioner to discontinue follow-up and were not interviewed for this study." - Anonymous Online Contributor
"The use of single drug treatment is the main method. In addition, most of patients use several drugs to be treated with. Even though the prevalence of bacterial vaginosis is high and only few patients are treated for bacterial vaginosis alone, the rate of bacterial vaginosis treatment has a decreasing trend of 20% over 10 years. Moreover, it is advisable that in the future, it is also necessary to educate patients about bacterial vaginosis and treat bacterial vaginosis so that they would understand what triggers abnormal body states." - Anonymous Online Contributor
"Men who have sex with men have a 4- to 6-fold higher chance of acquiring gonorrhea than women. Prevention of infections should therefore target both men and women." - Anonymous Online Contributor
"Gonorrhea infection continues to be primarily transmitted to males via multiple routes. Males and females often play different roles in the sexual contact chains of infection, suggesting that sexual behavior are often the key factor that causes gonorrhea infections." - Anonymous Online Contributor
"There have been no other clinical trials investigating new therapies for gonorrhea. There is much interest in research in this field to determine the best treatment for gonorrhea. Clinical trials on this topic are therefore needed. [Power(https://www.accessdata.fda.gov/datashow/ctb/clinicaltrials.htm)] [Power(http://www.withpower.com/clinical-trials/clinical-trial-pages) permits you to research clinical trials. These trials tailor to your condition, treatment, and location." - Anonymous Online Contributor
"This trial is enrolling patients at risk for long-term treatment-related side effects using the current standard of care for gonorrhea patients. Although the frequency of some side effects is higher in participants than the general population, the severity and potential burden of these effects are not clear. Clinical trials help to gauge the risks of side effects and how to monitor for them through the use of outcome measures. If you want to join a gonorrhea clinical trial, you can power to find recent trials by condition, treatment, or location." - Anonymous Online Contributor