F-18 Fluoroethyltyrosine (FET) for Cancer
This study is evaluating whether a new imaging agent may help doctors see tumors better during a PET scan.
See full descriptionAbout the trial for Cancer
Treatment Groups
This trial involves 2 different treatments. F-18 Fluoroethyltyrosine (FET) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex of any age. You must have received 1 prior treatment for Cancer or one of the other 8 conditions listed above. There are 6 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether F-18 Fluoroethyltyrosine (FET) will improve 2 primary outcomes and 2 secondary outcomes in patients with Cancer. Measurement will happen over the course of Day 1.
Patient Q & A Section
What are the signs of cancer?
The signs and symptoms of cancer are quite variable, depending on the type of cancer. Common signs in breast, cervix and colon cancer include lump in the breast, persistent vaginal bleeding or abdominal pain for colorectal cancer, and persistent, recurrent or unexplained vaginal bleeding or bleeding after sexual intercourse for cancers of the cervix, anus and uterus. Common signs of lymphoma include a painless soft lump in breast. Signs of lung cancer include a cough or worsening shortness of breath. Common signs of melanoma include a mole or bump on the skin, black, itchy bumps that don't heal completely, bleeding from nail, or an ulcer inside the nail.
How many people get cancer a year in the United States?
More than 25 million annual new cancer cases will be diagnosed in the United States in 2020. About 35% of all new cases will be breast cancer, 14% will be non-Hodgkin lymphoma, 12% will be colorectal cancer, and 9% will be prostate cancer. On average, men are at risk for being diagnosed with cancer at a younger age, and women at a later age, compared to the general population. The incidence, prevalence and mortality of various forms of cancer differ from year to year. More than 5.7 million people in the United States could be diagnosed with cancer in 2019.
What causes cancer?
In order to understand the complex pathogenesis of cancer, it will become increasingly important to understand how the body normally defends itself in the face of harmful stimuli such as tobacco smoke, asbestos fibers, and X-rays.
What are common treatments for cancer?
Most cancer patients receive a prescription medication; but sometimes these patients receive complementary treatment(s), which are often not prescribed on a regular basis, for example: homeopathy, herbal medicines, acupuncture, acupuncture-moxibustion, or dietary supplements as part of the cancer treatment.
What is cancer?
It is time we acknowledge the human price that cancer has caused in our communities. It is time we unite in our effort to raise awareness of the disease and in our call for funding of research through the U.S. Community Cancer Network and American Cancer Society. Let us fight together to see that these funds continue to support the best and most effective cancer treatments and that each family is given the best care possible.
What is the primary cause of cancer?
The primary cause of cancer is not simple. It is multiple and it is also a complex relationship between the patient, the tumor cells and the environment. The interaction of the factors result in different types of cancer at different sites. Cancer prevention and cancer treatment should targets only those important variables and factors that contribute to tumorigenesis and subsequent progression.
What does f-18 fluoroethyltyrosine (fet) usually treat?
Results from a recent paper demonstrates the value of determining drug levels. The FET PET scan has shown that tumor uptake of FET is a good indicator of tumor burden in a majority of subjects. The scan helps to predict which patients' tumors respond to therapy and when patients experience clinically significant response.
Have there been other clinical trials involving f-18 fluoroethyltyrosine (fet)?
The present study indicates that PET or other imaging modalities cannot replace TST for the detection of [thyroid cancer](https://www.withpower.com/clinical-trials/thyroid-cancer) during evaluation of patients with elevated serum TSH, particularly in patients with differentiated thyroid carcinoma.
What is f-18 fluoroethyltyrosine (fet)?
Fet is an amine used to image the central nervous system(CNS). It has also been reported to cause neurotoxicity in high plasma levels and hence is not used clinically at the doses that have been used in this study. The LD of fet is approximately 1.5 mg/kg. Fet also has low (6% bioavailability) protein binding. Fet will be readily metabolized and eliminated via the biliary system, particularly the cytochrome P450 enzymes.
How serious can cancer be?
I have known many people that died of cancer and none of them seemed to die quick enough for me to complain. In spite of all the efforts people make to save their lives, they still die. I have learned that even though there are some benefits to a good quality of life, there are also some limitations to what people are able to give up to their survival. I have realized that we cannot cure everyone from cancer. And I believe that to be successful in our struggle to save our lives from cancer, it comes down to the people’s will to live. I do believe that to achieve high quality of lifes we have to commit to living, no matter how difficult it is.
How quickly does cancer spread?
After radical surgery cancer does not spread quickly - cancer cells are still found in most organs 2 years later. Yet for many years cancer has been known so doctors have wondered whether cancer spreads or whether it is just metastasising. We now know that cancer spreads very slowly - and this is one of the first pieces of data to explain that cancer is not just 'a disease of fast growth and spread'.